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Letter to the Editor

Aortic Dissection After Sildenafil-induced Erection

Anna Nachtnebel, MD, Claudia Stöllberger, MD, Marek Ehrlich, MD, Josef Finsterer, MD
Volume: 99 Issue: 10 October, 2006

Abstract:

We report on a patient who experienced vomiting, diarrhea and abdominal pain shortly after ingestion of sildenafil and was found to have aortic dissection upon admission to the hospital. To our knowledge, this has not been previously reported. Vomiting and diarrhea are not known manifestations of aortic dissection.

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References:

1. Famularo G, Polchi S, Di Bona G, et al. Acute aortic dissection after cocaine and sildenafil abuse. J Emerg Med 2001;21:78–79.
 
2. Vlachopoulos C, Hirata K, O'Rourke MF. Effect of sildenafil on arterial stiffness and wave reflection.Vasc Med 2003;8:243–248.
 
3. Mochida H, Inoue H, Takagi M, et al. Sildenafil and T-1032, phosphodiesterase type 5 inhibitors, showed a different vasorelaxant property in the isolated rat aorta. Eur J Pharmacol 2002;440:45–52.
 
4. Tantini B, Manes A, Fiumana E, et al. Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells. Basic Res Cardiol 2005;100:131–138.
 
5. Herrmann HC, Chang G, Klugherz BD, et al. Hemodynamic effects of sildenafil in men with severe coronary artery disease. New Engl J Med 2000;342:1622–1626.
 

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