Original Article

Association between Weight Change, Health Outcomes, and Mortality in Older Residents in Long-Term Care

Authors: Wei Zhou, MD, Andrzej Kozikowski, PhD, Renee Pekmezaris, PhD, James Lolis, MD, Barbara Tommasulo, MD, Joanna Fishbein, MPH, Gisele Wolf-Klein, MD

Abstract

Objectives: Despite the numerous health risks associated with being overweight, the effect of weight loss on health and longevity remains controversial, particularly in older adults. We explored the association among weight changes, health outcomes, and mortality in older residents of a skilled nursing facility.

Methods: A 6-year retrospective chart review of residents of a long-term care facility was conducted, collecting monthly weights in addition to the clinical and demographic data of all residents for at least 1 year. Weight changes of 5% from baseline month 1 through month 12 were classified as stable, loss, or gain. Demographics, body mass index (BMI), comorbidities, number of hospitalizations, and mortality were analyzed. The association between weight change (and other demographic and clinical variables) and mortality outcomes, as well as number of hospitalizations, was assessed using the χ2 test, the Fisher exact test, Poisson regression, or negative binomial regression, as appropriate.

Results: A total of 116 residents fit inclusion criteria; the median age was 84 years, with 71.6% being women and 88.7% white. The median length of stay was 877.5 days. Median body weight at baseline was 137.3 lb with a BMI of 23.5. More than one-third (36.2%) of residents had stable weight, 37.9% gained weight, and 25.9% lost weight during their stay. Neither weight change category nor baseline BMI was significantly associated with mortality (P = 0.056 and P = 0.518, respectively). Multivariable models showed that receiving supplementation (P = 0.04) and having hypertension (P = 0.04) were significant predictors of mortality after adjusting for the other factors. Losing >5% body weight (compared with maintaining stable weight; P = 0.0097), being a man (P = 0.0104), receiving a supplement (P = 0.0171), and being fed by tube (P = 0.0004) were associated with an increased number of hospitalizations after covariate adjustment.

Conclusions: Weight fluctuation and baseline BMI do not appear to be associated with increased risk of death in residents in a skilled nursing facility. Weight loss was associated with an increased number of hospitalizations, however.

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References

1. World Health Organization. Global health risks: mortality and burden of disease attributable to selected major risks. http://www.who.int/healthinfo/global_burden_disease/GlobalHealthRisks_report_full.pdf. Published 2009. Accessed May 1, 2017.
 
2. Pollack A. A.M.A. Recognizes obesity as a disease. http://www.nytimes.com/2013/06/19/business/ama-recognizes-obesity-as-a-disease.html. Published 2013. Accessed May 17, 2017.
 
3. Oreopoulos A, Kalantar-Zadeh K, Sharma AM, et al. The obesity paradox in the elderly: potential mechanisms and clinical implications. Clin Geriatr Med 2009;25:643-659.
 
4. Seidell JC, Visscher TL. Body weight and weight change and their health implications for the elderly. Eur J Clin Nutr 2000;54(Suppl 3):S33-S39.
 
5. Tayback M, Kumanyika S, Chee E. Body weight as a risk factor in the elderly. Arch Intern Med 1990;150:1065-1072.
 
6. Corrada MM, Kawas CH, Mozaffar F, et al. Association of body mass index and weight change with all-cause mortality in the elderly. Am J Epidemiol 2006;163:938-949.
 
7. Janssen I, Mark AE. Elevated body mass index and mortality risk in the elderly. Obes Rev 2007;8:41-59.
 
8. Visscher TL, Rissanen A, Seidell JC, et al. Obesity and unhealthy life-years in adult Finns: an empirical approach. Arch Intern Med 2004;164:1413-1420.
 
9. Flegal KM, Graubard BI, Williamson DF, et al. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005;293:1861-1867.
 
10. Osher E, Stern N. Obesity in elderly subjects: in sheep’ clothing perhaps, but still a wolf! Diabetes Care 2009;32(Suppl 2):S398-S402.
 
11. Heiat A, Vaccarino V, Krumholz HM. An evidence-based assessment of federal guidelines for overweight and obesity as they apply to elderly persons. Arch Intern Med 2001;161:1194-1203.
 
12. Auyeung TW, Lee JS, Leung J, et al. Survival in older men may benefit from being slightly overweight and centrally obesea 5-year follow-up study in 4,000 older adults using DXA. J Gerontol A Biol Sci Med Sci 2010;65:99-104.
 
13. Takata Y, Ansai T, Soh I, et al. Association between body mass index and mortality in an 80‐‐ population. J Am Geriatr Soc 2007;55:913-917.
 
14. Andreyeva T, Michaud PC, van Soest A. Obesity and health in Europeans aged 50 years and older. Public Health 2007;121:497-509.
 
15. Hubbard RE, Lang IA, Llewellyn DJ, et al. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci 2010;65:377-381.
 
16. Imai K, Gregg EW, Chen YJ, et al. The association of bmi with functional status and self‐ health in US adults. Obesity (Silver Spring) 2008;16:402-408.
 
17. Somes GW, Kritchevsky SB, Shorr RI, et al. Body mass index, weight change, and death in older adults: the systolic hypertension in the elderly program. Am J Epidemiol 2002;156:132-138.
 
18. Newman AB, Yanez D, Harris T, et al. Weight change in old age and its association with mortality. J Am Geriatr Soc 2001;49:1309-1318.
 
19. Locher JL, Roth DL, Ritchie CS, et al. Body mass index, weight loss, and mortality in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2007;62:1389-1392.
 
20. Zajacova A, Ailshire J. Body mass trajectories and mortality among older adults: a joint growth mixture-discrete-time survival analysis. Gerontologist 2014;54:221-231.
 
21. Ryan C, Bryant E, Eleazer P, et al. Unintentional weight loss in long-term care: predictor of mortality in the elderly. South Med J 1995;88:721-724.
 
22. Sullivan DH, Johnson LE, Bopp MM, et al. Prognostic significance of monthly weight fluctuations among older nursing home residents. J Gerontol A Biol Sci Med Sci 2004;59:M633-M639.
 
23. Lee JS, Auyeung TW, Chau PP, et al. Obesity can benefit survival-a 9-year prospective study in 1614 Chinese nursing home residents. J Am Med Dir Assoc 2014;15:342-348.
 
24. Pizzato S, Sergi G, Bolzetta F, et al. Effect of weight loss on mortality in overweight and obese nursing home residents during a 5-year follow-up. Eur J Clin Nutr 2015;69:1113-1118.
 
25. Owens IPF. Sex differences in mortality rates. Science 2002;297:2008-2009.
 
26. Mathers CD, Sadana R, Salomon JA, et al. Healthy life expectancy in 191 countries, 1999. Lancet 2001;357:1685-1691.
 
27. Kraemer S. The fragile male. BMJ 2000;321:1609-1612.
 
28. Pan L, Fergusson D, Schweitzer I, et al. Ensuring high accuracy of data abstracted from patient charts: the use of a standardized medical record as a training tool. J Clin Epidemiol 2005;58:918-923.
 
29. Hess DR. Retrospective studies and chart reviews. Respir Care 2004;49:1171-1174.
 
30. Gearing RE, Mian IA, Barber J, et al. A methodology for conducting retrospective chart review research in child and adolescent psychiatry. J Can Acad Child Adolesc Psychiatr 2006;15:126-134.
 
31. Centers for Medicare and Medicaid Services. Nursing Home Data Compendium 2013 Edition. http://www.cms.gov/Medicare/Provider-Enrollment-and_Certification/CertificationandComplianc/downloads/nursinghomedatacompendium_508.pdf. Accessed March 1, 2016.