Invited Commentary

Commentary on “Safety Profile of High-Dose Statin Therapy in Geriatric Patients with Stroke”

Authors: Paul R. Casner MD, PhD

Abstract

For many geriatricians it is not unusual to have patients in their 80s and 90s, and even an occasional centenarian. Patients are living longer, often in spite of multiple diseases. As people age, their comorbidities increase; thus, older patients are more prone to have cardiovascular and cerebrovascular disease, as well as diabetes mellitus, chronic obstructive pulmonary disease (COPD), arthritis, and cancer.

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References

1. Vogelmeier C, Hederer B, Glaab T, et al. Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med. 2011; 364: 1093–1103.
 
2. Manocha D, Bansal N, Gumaste P, et al. Safety profile of high dose statin therapy in geriatric patients with stroke. South Med J. 2013; 106: 658–664.
 
3. Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006; 355: 549–559.
 
4. Zulman DM, Sussman JB, Chen X, et al. Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med. 2011; 26: 783–790.
 
5. McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004; 56: 163–184.