For the integrated multidisciplinary approach to patient care

Return to the Southern Medical Journal

Current User S2 Access Level: -1 ()
CAN NOT ACCESS LEVEL 2

Duloxetine-Induced Tako-Tsubo Cardiomyopathy: Implications for Preventing a Broken Heart

Richard G. Trohman, MD, Christopher Madias, MD
Volume: 104 Issue: 5 May, 2011

Abstract:

Agatha Christie captured her readers with mystery. Robert Ripley fascinated us with a vast assortment of the bizarre and unusual. It is, therefore, not surprising that we are intrigued by the unsolved puzzle of tako-tsubo cardiomyopathy. In this issue of the Southern Medical Journal, Rotondi et al. help extend the spectrum of pharmacologic agents with potential to precipitate this syndrome.1

Article:

This content is limited to qualifying members. Please click on an option below to view in full. Click here to compare all member plans.

Login

Silver/Gold members login for full access. Other members login to view purchase options.

Create a New Account

Create a new complimentary account/login to view purchase options.

Images:

This content is limited to qualifying members. Please click on an option below to view in full. Click here to compare all member plans.

Login

Silver/Gold members login for full access. Other members login to view purchase options.

Create a New Account

Create a new complimentary account/login to view purchase options.

References:

1. Rotondi F, Manganelli F, Carbone G, et al. "Tako-tsubo" cardiomyopathy and duloxetine use. South Med J 2011;104:345-347.
 
2. Dote K, Sato H, Tateishi H, et al. Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases [in Japanese]. J Cardiol 1991;21:203-214.
 
3. Virani S, Khan AN, Mendoza CE, et al. Takotsubo cardiomyopathy, or broken-heart syndrome. Tex Heart Inst J 2007;34:76-79.
 
4. Sharkey SW, Windenburg DC, Lesser JR, et al. Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy. J Am Coll Cardiol 2010;55:333-341.
 
5. Wittstein IS, Thiemann DR, Lima JA, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005;352:539-548.
 
6. Colucci VJ, Berry BD. Heart failure worsening and exacerbation after venlafaxine and duloxetine therapy. Ann Pharmacother 2008;42:882-886.
 
7. Lantz RJ, Gillespie TA, Rash TJ, et al. Metabolism, excretion and pharmacokinetics of duloxetine in healthy human subjects. Drug Metab Dispos 2003;31:1142-1150.
   
9. Bergman BR, Reynolds HR, Skolnick AH, et al. A case of apical ballooning cardiomyopathy associated with duloxetine. Ann Intern Med 2008;149:218-219.
 
10. Depression statistics. Available at: http://www.depressionstatistics.org/. Accessed January 26, 2011.
 

This content is limited to qualifying members. Please click on an option below to view in full. Click here to compare all member plans.

Login

Silver/Gold members login for full access. Other members login to view purchase options.

Create a New Account

Create a new complimentary account/login to view purchase options.

This content is limited to qualifying members. Please click on an option below to view in full. Click here to compare all member plans.

Login

Silver/Gold members login for full access. Other members login to view purchase options.

Create a New Account

Create a new complimentary account/login to view purchase options.

Permissions