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Evolution of Brunner Gland Hamartoma Associated with Helicobacter pylori Infection

Ravi R. Kurella, MD, Hanumantha R. Ancha, MD, Sanam Hussain, MD, Stan A. Lightfoot, MD, Richard Harty, MD
Volume: 101 Issue: 6 June, 2008

Abstract:

The pathogenesis of Brunner gland hamartoma of the duodenum is unknown. This case report describes the chronology of the development of Brunner gland hamartoma from Brunner gland hyperplasia over a 12-year interval. The study subject, a 64-year-old man with chronic iron deficiency anemia, underwent serial upper endoscopies during this period. Repeated endoscopies demonstrated the evolution of Brunner gland hyperplasia, as manifest endoscopically by a submucosal mass, to a pedunculated polyp with histologic features of Brunner gland hamartoma. The duodenal polypoid mass was removed by snare polypectomy. The patient also had a chronic Helicobacter pylori infection of the stomach. This report details the time-dependent evolution of Brunner gland hyperplasia to hamartoma in association with chronic gastric H. pylori infection.


Key Points


* The evolution of Brunner gland hyperplasia to hamartoma is time-dependent.


* Chronic Helicobacter pylori infection is associated with the development of Brunner gland hamartoma.

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