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Original Article

Impact of Tracheal Mucosa Involvement on Clinical Characteristics of Sarcoidosis

Ding Xin-Min, MD, Xu Qin-Zhi, MD, Duan Yun-You, MMed, Zhang Chun-Yan, MMed, Pen Chao-Sheng, MMed, Ning Hao-Yong, MD, Li Yong-Qun, MMed, Meng Ji-Guang, MMed, Nie Zhou-Shan, MMed, Feng Hua-Song, MMed
Volume: 104 Issue: 5 May, 2011

Abstract:

Objectives: To investigate the impact of tracheal mucosa involvement on the clinical features of sarcoidosis.


Methods: The clinical data of sarcoidosis patients with (Group A, n = 26) and without (Group B, n = 61) tracheal mucosa involvement were evaluated retrospectively.


Results: The proportion of patients suffering from cough in Group A was 92.3%, which was significantly higher than that in Group B (49.2%). The level of serum angiotensin-converting enzyme I (SACE) in Group A (60.7 ± 27.8 IU/L) was significantly higher than that in Group B (44.5 ± 31.9 IU/L). The proportion of lymphocytes in the bronchoalveolar lavage fluid (BALF) in Group A was significantly higher than that of Group B (45.3 ± 16.8% and 36.7 ± 15.1%, respectively; P = 0.047). The ratio of CD4 to CD8 in Group A was significantly higher than that in Group B (7.6 ± 5.4 and 3.1 ± 3.2, respectively; P = 0.005). In Group A, 84.6% patients received drug treatment, with a spontaneous remission rate of 15.4%. In Group B, 50.2% patients received drug treatment and the spontaneous remission rate was as high as 49.2%.


Conclusions: Sarcoidosis with tracheal mucosa involvement that can lead to cough and other respiratory symptoms, may be a manifestation of sarcoidosis activity, and usually requires drug treatment (including corticosteroid treatment).

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References:

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