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Premature Delivery Following Premature Rupture of Membranes: Increasing Frequency with Disappointing Outcome

John D. Yeast, MD, MSPH
Volume: 99 Issue: 7 July, 2006

Abstract:

Over 4,000,000 infants are born each year in the United States. Preterm delivery, primarily as a result of preterm labor (PTL) and preterm premature rupture of the membranes (PPROM), is the greatest contributor to newborn and infant morbidity and mortality, far exceeding other complications of pregnancy. In spite of many innovations in the management of pregnancy and threatened preterm labor, the risk of preterm delivery continues to rise. In 2004, 12.5% of all deliveries were preterm.1 That represents a 32% increase since 1952, and a 15% rise in preterm deliveries since 1990.

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References:

1. Hamilton B, Martin J, Ventura S, et al. Births: Preliminary data for 2004. National Vital Statistics Reports. Vol 54, No. 8. Hyattsville, Maryland, National Center for Health Statistics, 2005.
 
2. Weber C, Weninger M, Klebermass K, et al. Mortality and morbidity in extremely preterm infants (22 to 26 weeks of gestation): Austria 1999-2001. Wien Klin Wochenschr 2005;117:740–746.
 
3. Stoll B, Hansen N, Adams-Chapman I, et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004;292:2357–2365.
 
4. Marlow N, Wolke D, Bracewell M, et al. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med 2005;353:9–19.
 
5. Huttenlocher P, Dabholkar A. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol 1997;387:167–178.
 

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