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"Tako-Tsubo" Cardiomyopathy and Duloxetine Use

Francesco Rotondi, MD, Fiore Manganelli, MD, FESC, Giannignazio Carbone, MD, Giovanni Stanco, MD
Volume: 104 Issue: 5 May, 2011

Abstract:

We report the case of a 68-year-old woman in whom the use of duloxetine, a potent serotonin and norepinephrine reuptake inhibitor, was associated with "tako-tsubo" cardiomyopathy (TTC). Although several pathophysiological mechanisms for TTC have been proposed, available evidence suggests that an excess of catecholamines may play a major role. Our patient had a history of myocardial infarction with normal coronary arteries, probably the first manifestation of TTC. We speculate that duloxetine may have precipitated TTC by increasing plasma catecholamine concentration in a predisposed patient.

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