Correspondence

Treatment of Acute Isoniazid Toxicity of Unknown Dose

Authors: Hüsnü Kürşad, MD, Mehmet Kizilkaya, MD, Murat Şahin, MD, Nazım Dogan, MD, Asım İlgaz, MD

Abstract

To the Editor:


Isoniazid is a bactericidal antituberculosis agent. 1 Overdose of isoniazid is characterized by seizures, metabolic acidosis, and coma. 2 Because it can result in death if untreated, early consideration of the possibility of isoniazid poisoning is important. We describe a patient treated with pyridoxine after an isoniazid overdose.

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References

1. Temmerman W, Dhondt A, Vandewoude K. Acute isoniazid intoxication: seizures, acidosis and coma. Acta Clin Belg 1999; 54: 211–216.
2. Brent J, Vo N, Kulig K, Rumack BH. Reversal of prolonged isoniazid-induced coma by pyridoxine. Arch Intern Med 1990; 150: 1751–1753.
3. Yona A, Syama A, Baumal J, et al: Introduction, in Ellenhorn MJ (ed): Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. Baltimore, Williams & Wilkins, 1997, ed 2, pp 224–249.
4. Osborn H: Antituberculosis agents, in Goldfrank LR, Flomenbaum N, Lewin N, Howland MA, Hoffman R, Nelson L (eds): Goldfrank's Toxicologic Emergencies. Stamford, Appleton & Lange, 1998, ed 6, pp 727–737.