March 2015, Volume 108 - Issue 3

pANCA Positivity Predicts Lower Clinical Response to Infliximab Therapy among Patients with IBD

Douglas L. Nguyen, MD, Emily T. Nguyen, PharmD, Matthew L. Bechtold, MD

Abstract: Objectives: Several studies have been performed evaluating the role of perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) to predict early clinical response among patients with inflammatory bowel disease (IBD) who are undergoing infliximab therapy. The results of...

(pp 139-143)

Rural-Urban Differences in HIV Viral Loads and Progression to AIDS among New HIV Cases

Sharon Weissman, MD, Wayne A. Duffus, MD, PhD, Medha Iyer, MD, PhD, Hrishikesh Chakraborty, DrPH, Ashok Varma Samantapudi, MSPH, Helmut Albrecht, MD

Abstract: Objective: The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic in the United States has shifted to the South, where an increasing proportion is occurring in rural areas. We sought to gain a better understanding of the affected rural...

(pp 180-188)

Commentary on “Time to Dedifferentiate”

Irene Alexandraki, MD, MPH

Abstract: Medical education has continued to evolve since the Flexner report was published more than 100 years ago. Perpetual changes in the healthcare delivery system and societal expectations for high quality in both medical training and practice have led to a reform in medical...

(pp 200-201)

CME Instructions

None Available

Abstract: Each CME activity should take approximately 1 hour to complete. Each CME activity includes the following: Full text article Article CME information CME test Evaluation Learner-directed phase CME activities within the online journal CME on the Southern Medical...

(pp -)

Uveal Melanoma in the First 4 Decades of Life

Merve Sagus, Agop Y. Bedikian, MD

Abstract: Objectives: According to reports in the clinical literature, metastatic uveal melanoma in young adults has not been well studied. This article describes the clinical characteristics and natural history of patients who were diagnosed as having uveal melanoma in the first 4...

(pp 158-163)

Commentary on “Religion, Sense of Calling, and the Practice of Medicine: Findings from a National Survey of Primary Care Physicians and Psychiatrists”

John R. Peteet, MD

Abstract: How many physicians feel a calling to medicine, and does it matter? In this issue of the Southern Medical Journal, Yoon and colleagues1 augment a small but growing literature on a sense of calling, which suggests both connections with self-efficacy2 and satisfaction in...

(pp 196-197)

Religion, Sense of Calling, and the Practice of Medicine: Findings from a National Survey of Primary Care Physicians and Psychiatrists

John D. Yoon, MD, Jiwon H. Shin, MA, Andy L. Nian, BS, Farr A. Curlin, MD

Abstract: Objectives: A sense of calling is a concept with religious and theological roots; however, it is unclear whether contemporary physicians in the United States still embrace this concept in their practice of medicine. This study assesses the association between religious...

(pp 189-195)

Vitamin D Deficiency in Pediatric Patients with Cystic Fibrosis: Associated Risk Factors in the Northern United States

Amy Hughes Lansing, MS, Catherine McDonald, PhD, RD, Raza A. Patel, MD, MPH, Suzanne Meihls, RN, Kody Crowell, MD, Barbara Chatfield, MD, John F. Pohl, MD

Abstract: Objectives: Cystic fibrosis (CF) is associated with vitamin D deficiency, which can lead to adverse effects including recurrent pulmonary infections and osteoporosis. We longitudinally investigated calcifediol or 25-hydroxyvitamin D (25(OH)D) levels for our pediatric...

(pp 164-169)

Time to Dedifferentiate

Farrin A. Manian, MD, MPH

Abstract: “One of the mechanisms associated with natural regeneration is dedifferentiation, which involves a terminally differentiated cell reverting back to a less differentiated stage from within its own lineage.”1 “ The only part of the mature mammalian limb that possesses...

(pp 198-199)

CME Article: Abuse of Medications That Theoretically Are Without Abuse Potential

Roy R. Reeves, DO, PhD, Mark E. Ladner, MD, Candace L. Perry, MD, Randy S. Burke, PhD, Janet T. Laizer, MD

Abstract: The potential for abuse of medications that are controlled substances is well known. Abuse of certain noncontrolled prescription drugs and over-the-counter medications also may occur. To some degree, any medication that exerts psychoactive effects may be abused if taken in...

(pp 151-157)

Trends in Cigarette Smoking and Obesity in Appalachian Kentucky

Nancy E. Schoenberg, PhD, Bin Huang, DrPH, Srihari Seshadri, MBBS, MPH, Thomas C. Tucker, PhD

Abstract: Objectives: The southern region of the United States, particularly central and southern Appalachia, has long been identified as an area of health inequities. An updated and more complete understanding of the association among the leading risk factors for such health...

(pp 170-177)

Commentary on “pANCA Positivity Predicts Lower Clinical Response to Infliximab Therapy among Patients with IBD”

Edmund Leung

Abstract: Inflammatory bowel disease (IBD) is a debilitating condition that presents as a spectrum of both gastrointestinal and extraintestinal disorders. The etiology remains unknown, although it is theorized to be immunologically mediated. Despite careful history and physical...

(pp 144)

Rules for Improving Pharmacotherapy in Older Adult Patients: Part 2 (Rules 6-10)

James M. Wooten, PharmD

Abstract: The population of older adult patients in the United States is growing each year. Appropriate pharmacotherapy has allowed many older patients to live longer and maintain healthy lives. Unfortunately, the inappropriate utilization of medications can be harmful to older adult...

(pp 145-150)

Commentary on “Trends in Cigarette Smoking Obesity in Appalachian Kentucky”

Francisco Soto Mas, MD, PhD

Abstract: In this issue of the Southern Medical Journal, Schoenberg and colleagues not only explore the role of smoking and obesity in mortality and morbidity rates in Appalachian Kentucky but they also present a case that further supports the need for analyzing health problems with...

(pp 178-179)