Original Article
Efficacy and Safety of Direct Oral Anticoagulants Compared to Warfarin in Patients with Cirrhosis and Splanchnic Vein Thrombosis
Objective: The incidence of splanchnic vein thrombosis (SVT) is reported to be
SMJ articles in the category "anticoagulation"
Original Article
CME Article: Safety of Nonvitamin K Antagonists Compared with Warfarin in Patients with Atrial Fibrillation and End-Stage Kidney Disease
Objectives: This study evaluated the occurrence of major bleeding following the initiation of oral anticoagulation therapy in patients with end-stage kidney disease (ESKD) in a community teaching hospital. Methods: This was a single-center retrospective study that enrolled patients admitted to the study hospital with ESKD and who received oral anticoagulation…
Review Article
Pharmacologic Agents Used to Reverse the Anticoagulant Effect of Common Anticoagulants
Numerous oral and parenteral anticoagulant drugs are now available for clinical use. Understanding the precise pharmacologic properties of each anticoagulant is imperative for those practitioners who prescribe these drugs, including knowing the current recommendations for reversing the anticoagulant effect of each anticoagulant. This review provides a brief description of the…
Original Article
Perioperative Resumption of Direct Oral Anticoagulants: Review of the Mayo Clinic Experience
Objective: We aimed to review recommendations for the postoperative resumption of direct oral anticoagulants (DOACs) and report complications 30 days postoperatively. Methods: We retrospectively reviewed patients receiving DOAC therapy who underwent preoperative evaluations from January 1, 2015 through May 30, 2018. We noted days that DOAC therapy was withheld, postoperative…
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anticoagulation 12
Original Article
Utility of Hemoccult Testing Before Therapeutic Anticoagulation in Venous Thromboembolism
Objectives: Fecal occult blood testing (FOBT) is performed routinely before starting therapeutic anticoagulation in patients despite it never being validated to predict gastrointestinal bleeding (GIB) risk. Our objective was to determine the utility in checking the guaiac FOBT test (gFOBT) before initiating therapeutic anticoagulation in patients with a new diagnosis…
Review Article
Role of Direct Oral Anticoagulants in the Management of Anticoagulation
For decades, vitamin K antagonists (VKAs) have been the oral treatment of choice for many thromboembolic conditions. The limitations of VKAs include the need for monitoring through blood testing, drug interactions, and narrow therapeutic windows. These shortcomings have led to the development of direct oral anticoagulants. These new oral agents…
Review
Comparing New Anticoagulants
For years, the pharmaceutical industry has been trying to find a safe and effective drug to replace warfarin. Although warfarin is an effective anticoagulant, its pharmacology, adverse effects, and risk profiles dictate that patients taking this medication must be monitored judiciously. The US Food and Drug Administration has approved two…
Case Report
Hyperprothrombinemia as a Result of a Possible Warfarin and Intravaginal Miconazole Interaction
Warfarin, a commonly prescribed anticoagulant, has many potential drug interactions. We describe a case of intravaginal miconazole potentiating the effects of warfarin in a patient previously stable on a consistent dose of 8.5 mg warfarin daily. Following a course of intravaginal miconazole and a dosage increase to 9 mg daily,…
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anticoagulation 12 drug interaction 2
Case Report
Acute Pylephlebitis Following Gastrointestinal Infection: An Unrecognized Cause of Septic Shock
Pylephlebitis is the septic thrombosis of the portal vein. Hypercoagulability and intra-abdominal sepsis are the main predisposing factors. A 25-year-old man presented to a primary health care center complaining of fever, epigastric pain, and jaundice. He was initially diagnosed with a gastrointestinal infection and alcoholic hepatitis and, due to his…
Case Report
Inflammatory Bowel Disease-Related Thoracic Aortic Thrombosis
Arterial and venous thromboembolisms have long been associated with inflammatory bowel disease (IBD) and can cause significant morbidity and mortality. We present a patient with aortic arch thrombosis embolizing to the left lower extremity during hospitalization for active ulcerative colitis (UC). The limb was preserved following emergent embolectomy. Thrombophilia was…
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anticoagulation 12 inflammatory bowel disease 10
Case Report
An Unusual Cause of Cerebral Venous Sinus Thrombosis: Prothrombin G20210A Gene Mutation
Cerebral venous sinus thrombosis represents less than 1% of all strokes, being an uncommon entity with a wide spectrum of clinical scenarios. We present a 45-year-old Hispanic female with a history of long-term oral contraceptive use who was diagnosed with cerebral venous sinus thrombosis due to a heterozygous carrier mutation…
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anticoagulation 12
Review Article
Preventing Warfarin-related Bleeding
Warfarin is one of the most common anticoagulants in current use. It maintains a narrow therapeutic index resulting in a significant amount of bleeding. Changes in concomitant medication use and acute illnesses are common causes of overanticoagulation. Monitoring regimens based on patient characteristics and the intensity and duration of anticoagulant…
