SMJ articles in the category "combination therapy"

Original Article

OPEN: Effects of Long-Term Combination LT4 and LT3 Therapy for Improving Hypothyroidism and Overall Quality of Life

Objectives: Hypothyroidism results in decreased mood and neurocognition, weight gain, fatigue, and many other undesirable symptoms. The American Association of Clinical Endocrinologists, the American Thyroid Association (ATA), and The Endocrine Society recommend levothyroxine (LT4) monotherapy as the treatment for hypothyroidism; however, after years of monotherapy, some patients continue to experience…

Posted in: combination therapy 6 hypothyroidism 8

Review Article

Type 2 Diabetes Mellitus: Managing Hemoglobin A1c and Beyond

Comprehensive glycemic control, as demonstrated by desirable glycated hemoglobin A1c (HbA1c), postprandial glucose (PPG), and fasting plasma glucose (FPG) levels, is imperative for managing patients with type 2 diabetes mellitus (T2DM). It is important to minimize fluctuations in blood glucose levels, as they are thought to contribute to both the…

Posted in: combination therapy 6 glycemic control 4 hypoglycemia 7

Review Article

Angiotensin Receptor Blockers for Management of Hypertension

The renin-angiotensin-aldosterone system (RAAS) plays a major role in blood pressure regulation and is thus an important therapeutic target in the management of hypertension. Angiotensin receptor blockers (ARBs), which interrupt RAAS overactivity by blocking a specific receptor that mediates the pathogenic activity of angiotensin II, represent a major addition to…

Posted in: combination therapy 6 Hypertension 39

Review Article

Rationale for Fixed-Dose Combination Therapy to Reach Lower Blood Pressure Goals

Expert committees in the United States and Europe formulated their currently recommended target blood pressures of <140/90 mm Hg or <130/80 mm Hg in persons with diabetes, chronic kidney disease, or coronary artery disease based on the totality of clinical data available at the time. However, accumulating evidence indicates that…

Posted in: angiotensin receptor blockers 4 Cardiovascular Disease 27 combination therapy 6 Hypertension 39

Review Article

Treating the Whole Patient for Optimal Management of Type 2 Diabetes: Considerations for Insulin Therapy

Primary care physicians are responsible for providing healthcare to most patients with type 2 diabetes. In this role, it is critical that physicians utilize a whole-patient treatment approach that includes lifestyle modifications and pharmacotherapy aimed to achieve glycemic control, in addition to the management of any comorbid conditions or risk…

Posted in: combination therapy 6 diabetes management 2 insulin 8

Review Article

Rationale for Combination Therapy in Hypertension Management: Focus on Angiotensin Receptor Blockers and Thiazide Diuretics

Despite recognition that hypertension is a major risk factor for cardiovascular events and mortality, blood pressure control rates remain low in the US population. Reflecting clinical trial results, hypertension management guidelines assert the clinical benefit of achieving current blood pressure goals and indicate that most patients will require 2 or…

Posted in: angiotensin receptor blockers 4 Cardiovascular Disease 27 combination therapy 6 Hypertension 39
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