SMJ articles in the category "drug-drug interactions"

Multidisciplinary Clinical Case Study

An Underappreciated and Prolonged Drug Interaction Leads to Ineffective Anticoagulation

A poorly understood significant drug–drug interaction compounded by ineffective communication among providers at times of care transition most likely contributed to multiple thromboembolic events in an 81-year-old patient. Increased awareness of drug interactions with direct oral anticoagulants (DOACs), as well as improved communication among inpatient and outpatient providers at the…

Posted in: direct oral anticoagulants 2 drug-drug interactions 2 transition of care 4

Case Report

Two Probable Cases of Serious Drug Interaction Between Clarithromycin and Colchicine

Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin. Key Points * Clinician should…

Posted in: clarithromycin 2 colchicine 2 drug-drug interactions 2
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