SMJ articles in the category "drug interaction"

Original Article

Prescriptions for a Toxic Combination: Use of Methotrexate Plus Trimethoprim-Sulfamethoxazole in the United States

Objectives: To determine the frequency of using the potentially toxic combination of methotrexate and trimethoprim-sulfamethoxazole (TMP-SMX) in outpatient practice in the United States. Methods: Data from the National Ambulatory Medical Care Survey for 1993–2010 were used to assess the frequency of using methotrexate with TMP-SMX and associated physician specialties and…

Posted in: acute lymphoblastic leukemia 3 Adverse event 2 drug interaction 2 polypharmacy 3

Case Report

Hyperprothrombinemia as a Result of a Possible Warfarin and Intravaginal Miconazole Interaction

Warfarin, a commonly prescribed anticoagulant, has many potential drug interactions. We describe a case of intravaginal miconazole potentiating the effects of warfarin in a patient previously stable on a consistent dose of 8.5 mg warfarin daily. Following a course of intravaginal miconazole and a dosage increase to 9 mg daily,…

Posted in: anticoagulation 12 drug interaction 2
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