Original Article

CME Article: Historical Alternans in the Emergency Department (H.A.t.E.D.) for Pain: An Analysis of Patient Pain Descriptors to Attending and Trainee Clinicians

Objectives: The concept of “historical alternans” (HA), a teaching folklore term referring to different descriptions of patient histories to trainees versus attending clinicians, can cause disjointed care and be a source of frustration for the trainee. Increased focus on the proper evaluation and treatment of pain in the emergency department…

Posted in: education 20 evaluation 3 history 5 pain 18 Residency 11

Review Article

Looking Into the Future of Cell-Based Therapy

Recent research points to the future of regenerative medicine. In the past year, a handful of research groups have demonstrated that mature, adult cells could be “reprogrammed” to a very primitive, embryonic state via the forced expression of four genes (Oct-3/4, c-Myc, Klf4, and Sox2). These induced pluripotent cells (or…

Posted in: development 2 history 5 stem cells 2

Review Article

The History of Lupus Erythematosus

This article explores the history of lupus erythematosus from the origins of the name to the most modern therapeutic advances. The review includes information about the origin of the name “lupus,” the first clear description of the skin lesions, the discovery of the systemic and discoid forms, and further advances…

Posted in: history 5

Original Article

Great Shakes: Famous People With Parkinson Disease

James Parkinson is credited with the first complete clinical description of the syndrome attributed to his name, Parkinson disease. It is recognized as the first syndrome defined after neurology became a specialty. Descriptions of Parkinson features are rare in antiquity, and famous people with this disorder have not been found…

Posted in: history 5 Parkinson disease 7

Review Article

Smallpox Vaccination in the Early 19th Century Using Live Carriers: The Travels of Francisco Xavier de Balmis

Realizing that the Spanish colonies were being devastated by epidemics of smallpox resulting in thousands of deaths, Charles IV, King of Spain, sent one of his court’s physicians to apply the recently discovered vaccine. Without refrigeration, the vaccine was passed from one child to another (boys taken out of orphanages)….

Posted in: history 5 smallpox 3 vaccination 11
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