Original Article

Evaluation of Multi-Drug Therapy for Leprosy in the United States Using Daily Rifampin

Objectives: To evaluate the occurrence of relapse of multibacillary leprosy after multi-drug treatment including daily rifampin. Methods: A retrospective review was performed utilizing data from the National Hansen’s Disease Program (NHDP) on patients with leprosy treated and followed from 1988-1997 who received multi-drug therapy including daily rifampin. The occurrence of…

Posted in: Hansen disease 2 leprosy 4

Case Report

False-Positive Amplified Mycobacterium tuberculosis Direct Tests in Skin Specimens of Leprosy

The amplified Mycobacterium tuberculosis (M tuberculosis) direct test (MTD) is reported to be a highly sensitive (92.6%) and specific (100%) test for the detection of M tuberculosis. We report two cases of human leprosy in which false-positive amplified MTD testing on skin biopsies led to initial misdiagnoses of cutaneous M…

Posted in: leprosy 4 Mycobacteria 2 tuberculosis 13

Case Report

Three Indigenous Cases of Leprosy in the Mississippi Delta

Three native-born patients from the Mississippi Delta presented with leprosy over a 13-month period. None had a history of foreign travel, contact with each other, or known leprosy patients. Two patients’ lesions lacked anesthesia, and all had a history of armadillo exposure. These cases add to the association of armadillo…

Posted in: leprosy 4 Mississippi 7

Review Article

Leprosy: A Case Series and Review

Hansen disease, historically known as leprosy, is caused by Mycobacterium leprae. The disease is rare in the United States but remains endemic among certain immigrant populations, and may manifest years after infection. The US military has a number of active duty troops originally from endemic countries. Recently, three US soldiers…

Posted in: Hansen disease 2 immigrant 2 leprosy 4 military 5
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