Original Article

Measures of Frailty in Homebound Older Adults

Objectives: Frailty, a geriatric syndrome associated with high morbidity and mortality, has rarely been assessed in homebound older adults. As such, we evaluated the prevalence of frailty among older adults enrolled in a home-based primary care program. b We measured frailty using the Fried Frailty Phenotype criteria of unintentional weight…

Posted in: frailty 8 multimorbidity 2 polypharmacy 3

Original Article

Impact of Polypharmacy on Seniors’ Self-Perceived Health Status

Objectives: Polypharmacy is common among older patients and is linked to increased risk of adverse health outcomes. This study aimed to explore the association of polypharmacy and self-perceived health status (SPHS) among geriatric patients. Methods: This cross-sectional analysis of longitudinal observational research used national survey data from 2005–2008. Multivariate logistic…

Posted in: geriatric 3 health status 4 medication 5 polypharmacy 3

Original Article

Prescriptions for a Toxic Combination: Use of Methotrexate Plus Trimethoprim-Sulfamethoxazole in the United States

Objectives: To determine the frequency of using the potentially toxic combination of methotrexate and trimethoprim-sulfamethoxazole (TMP-SMX) in outpatient practice in the United States. Methods: Data from the National Ambulatory Medical Care Survey for 1993–2010 were used to assess the frequency of using methotrexate with TMP-SMX and associated physician specialties and…

Posted in: acute lymphoblastic leukemia 3 Adverse event 2 drug interaction 2 polypharmacy 3
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