SMJ articles in the category "pulmonary hypertension"

Acknowledgment

Echocardiography-Defined Pulmonary Hypertension in Multiple Myeloma: Risk Factors and Impact on Outcomes

Objectives: Survival of patients with multiple myeloma (MM) has improved as a result of therapeutic advances. There is evidence that some patients with MM develop pulmonary hypertension (PH). The objective of this study was to identify risk factors of echocardiographic PH and its impact on outcomes of patients with MM….

Posted in: multiple myeloma 10 pulmonary hypertension 12

Review Article

Protective Effect of Pulmonary Hypertension Against Right-Sided Tamponade in Pericardial Effusion

Patients with pericardial effusion are susceptible to cardiac tamponade. A compressing circumferential pericardial effusion typically results in an equalization of intracardiac and pericardial pressure during diastole and a progressive collapse of the right atrium and ventricle. Pulmonary hypertension that increases the afterload of the right ventricle may result in elevated…

Posted in: pericardial effusion 4 pulmonary hypertension 12 tamponade 2

Original Article

Use of Pulmonary Arterial Hypertension-Specific Therapy in Non-WHO Group I Pulmonary Hypertension

Objectives: The development of pulmonary hypertension (PH) in non–World Health Organization group I PH adversely affects exercise capacity. It is unclear whether pulmonary artery hypertension (PAH)–specific drugs improve pulmonary hemodynamics and exercise capacity in such patients. Methods: We performed a retrospective chart review of consecutive patients with non–World Health Organization…

Posted in: chronic obstructive pulmonary disease 10 obstructive sleep apnea 7 pulmonary hypertension 12 sarcoidosis 15 therapy 6

Original Article

Differential Phenotype Profile between Main Right Ventricular Chamber and Outflow Tract in Chronic Pulmonary Hypertension: Echocardiographic Observation

Objectives: Right ventricular (RV) dilatation and systolic dysfunction are known remodeling changes occurring in chronic pulmonary hypertension and are likely the result of increases in pulmonary vascular resistance (PVR). It remains unclear whether PVR affects primarily the main RV chamber (mRVc) or the RV outflow tract (RVOT). Methods: Standard echocardiography…

Posted in: echocardiography 11 pulmonary hypertension 12 right ventricle 3

Original Article

Misclassification of Pulmonary Hypertension in Adults with Sickle Hemoglobinopathies Using Doppler Echocardiography

Objective: To compare the diagnostic utility of Doppler echocardiography–derived tricuspid regurgitant jet velocity (TRV) ≥2.5 m/s to right heart catheterization (RHC) in defining pulmonary hypertension (PH) in adult patients with sickle cell disease (SCD). Methods: This is a retrospective chart review of adults with SCD who had a TRV ≥2.5…

Posted in: echocardiography 11 pulmonary hypertension 12 sickle cell disease 28

Original Article

Should All Patients with Pulmonary Hypertension Undergo HIV Serologic Testing?

Objectives: To evaluate the yield of screening patients with pulmonary hypertension (PH) for human immunodeficiency virus (HIV) infection. Methods: We retrospectively reviewed the records of consecutive patients with PH seen at our institution from July 1992 to November 2008. We assessed HIV risk factors and history of HIV. We estimated…

Posted in: HIV 30 human immunodeficiency virus 23 pulmonary hypertension 12

Case Report

Constrictive-Like Physiology in Severe Pulmonary Hypertension: The Effect of the Valsalva Maneuver

We describe the case of a 37-year-old female with severe pulmonary hypertension on intravenous Remodulin® and Tracleer® who experienced presyncope following a six-minute walk. A transthoracic echocardiogram, in addition to showing the usual findings of chronic pulmonary hypertension, also demonstrated a noticeable increase in both mitral annular systolic and early…

Posted in: echocardiography 11 pulmonary hypertension 12

Case Report

Carboxyhemoglobin Formation Secondary to Nitric Oxide Therapy in the Setting of Interstitial Lung Disease and Pulmonary Hypertension

Carbon monoxide (CO) has been widely recognized as an exogenous poison, although endogenous mechanisms for its formation involve heme-oxygenase (HO) isoforms, more specifically HO-1, in the setting of oxidative stress such as acute respiratory distress syndrome, sepsis, trauma, and nitric oxide use have been studied. In patients with refractory hypoxemia,…

Posted in: nitric oxide 2 pulmonary hypertension 12

Original Article

Prevalence of Acute Vasoresponsiveness in Patients With Pulmonary Hypertension: Treatment Implications

Objective: Pulmonary hypertension (PH) is a serious and often progressive disorder that results in right ventricular dysfunction. The general reported rate of patients who are responders is 10%–26%. More recently, using the current criteria, the rate of acute vasodilator response was as low as 6%. This study used the most…

Posted in: pulmonary arterial hypertension 5 pulmonary hypertension 12 right heart catheterization 2

Original Article

The Successful Use of Phosphodiesterase Type 5 Inhibitors to Treat the Syndrome of Cor Pulmonale and Prerenal Azotemia with Diuresis of Anasarca (CorPRADA)

Background: The occurrence of deteriorating renal function test results along with the attempts at diuresis of anasarca has been described but not named, and no solution other than the standard treatment of related medical conditions such as congestive heart failure (CHF) and reducing or stopping diuretics has been offered. Phosphodiesterase…

Posted in: pulmonary hypertension 12

Review Article

Pulmonary Arterial Hypertension: Evaluation and Management

Pulmonary arterial hypertension (PAH), a rare disease involving the pulmonary vascular circuit, is defined as an elevation in pulmonary arterial pressures and is characterized by symptoms of dyspnea, chest pain, and syncope. If left untreated, the disease carries a high mortality rate, with the most common cause of death being…

Posted in: endothelin 2 pulmonary hypertension 12 pulmonary vascular disease 2

Case Report

Long-term Results After Addition of Sildenafil in Idiopathic PAH Patients on Bosentan

Idiopathic pulmonary arterial hypertension is a disease involving small muscular pulmonary arteries and arterioles. Treatment with prostacyclin analogs and endothelin receptor antagonists is the cornerstone of therapy in these patients. Recent evidence suggests that phosphodiesterase-5 inhibitors such as sildenafil may improve functional capacity and hemodynamics in patients with pulmonary arterial…

Posted in: endothelin 2 pulmonary hypertension 12 pulmonary vascular disease 2 sildenafil 2
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