SMJ articles in the category "Statins"

Multidisciplinary Clinical Case Study

When Statins Get Physical: A Curious Cause of Statin Myopathy

We present the case of a 61-year-old male with hyperlipidemia and lumbar radiculopathy admitted to our hospital with rhabdomyolysis attributed to the recent initiation of statin therapy. Despite aggressive fluid resuscitation and an initial declination in his creatine phosphokinase (CPK) levels, he had persistent myalgias with progressive weakness. Rheumatologic and…

Posted in: myopathy 4 Statins 8

Original Article

Effects of Statin Therapy in Patients with Systemic Lupus Erythematosus

Objectives: Systemic lupus erythematosus (SLE) is associated with a significant risk of cardiovascular mortality. The use of statins for lipid modulation and the prevention of cardiovascular disease in this population also may impart pleiotropic anti-inflammatory and immunomodulatory effects. Our aim was to identify studies that compared the use of statins…

Posted in: meta-analysis 5 Statins 8 systemic lupus erythematosus 9

Review Article

Statin-Associated Diabetes Mellitus: Review and Clinical Guide

A small but significant link between new-onset diabetes mellitus (NOD) and statin therapy was noted with rosuvastatin users in the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin study. Since then multiple analyses have further confirmed this association, with most studies demonstrating a modest…

Posted in: Cardiovascular Disease 27 diabetes mellitus 37 insulin resistance 4 Statins 8 type 2 diabetes mellitus 13

Original Article

Overtreatment and Undertreatment of Hyperlipidemia in the Outpatient Setting

Background: National guidelines recommend lipid-lowering therapy for patients with coronary heart disease (CHD), its equivalent (eg, diabetes mellitus, peripheral arterial disease, cerebrovascular disease), and those at high risk of CHD. Quality-of-care studies demonstrate that patients at high risk of CHD are undertreated. Overtreatment of patients at low risk of CHD…

Posted in: Hyperlipidemia 4 primary care 65 Statins 8 Treatment 22

Review

Recent Diabetes Issues Affecting the Primary Care Clinician

Diabetes accounts for millions of office visits each year to primary care offices in the United States. Successful care of the patient with type 2 diabetes requires not only focus on glucose management but also on comorbidities such as hypertension, dyslipidemia and obesity which are closely linked to microvascular and…

Posted in: Cardiovascular Disease 27 metformin 5 primary care 65 Statins 8 type 2 diabetes mellitus 13

Case Report

Resolution of Statin-Induced Myalgias by Correcting Vitamin D Deficiency

Correction of hyperlipidemia with statins is often limited by the side-effect of statin-induced myalgias. Vitamin D deficiency is also associated with myalgias that resolve with correction of the vitamin D deficiency. Myalgias associated with statin therapy may also resolve with correction of vitamin D deficiency. This case report presents a…

Posted in: Hyperlipidemia 4 Statins 8 vitamin D 17

Case Report

Rosuvastatin-Induced Thrombocytopenia

Rosuvastatin, a statin indicated for patients with primary hypercholesterolemia, mixed dyslipidemia and familial hypercholesterolemia, is well tolerated by most patients. Its most common adverse effects are gastrointestinal derangement, muscle aches and hepatitis. One rare complication of statin treatment is severe thrombocytopenia. The case of a 65-year-old patient who developed severe…

Posted in: rosuvastatin 3 Statins 8

Expired CME Article

C-Reactive Protein: The Harbinger of Cardiovascular Diseases

Coronary heart disease remains the major cause of mortality and morbidity in the United States and other western countries despite major advances in its treatment. During the last decades, many markers of coronary artery disease have been found which help predict future risk of cardiovascular events. High-sensitivity C-reactive protein has…

Posted in: Aspirin 7 atherosclerosis 13 high sensitivity C-reactive protein 3 inflammation 12 Statins 8
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