SMJ articles in the category "syndrome"

Case Report

Complete Currarino Triad Presenting with Diarrhea in a 7-Month-Old Girl

The Currarino triad is a complex genetic disorder characterized by multiple caudal anomalies. Currarino et al first described this syndrome in 1981 as a sacral bony defect, presacral mass, and an anorectal malformation. Patients with this disorder usually present with constipation and characteristic radiological findings. Early diagnosis is vital for…

Posted in: syndrome 7

Review Article

Cisplatin-Induced Renal Salt Wasting Syndrome

Cisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal impairment with a decline in glomerular filtration has been the classical nephrotoxicity of cisplatin. Renal salt wasting syndrome is yet another, though it is not common….

Posted in: cisplatin 2 syndrome 7

Case Report

Small Cell Lung Cancer with Paraneoplastic Lipase Production

Kulchitsky cells represent the cells of origin of small cell lung cancer (SCLC). They display an antigenic makeup characteristic of both the neural crest and epithelium and have been shown to secrete both polypeptide hormones and enzymes. The coexistence of two or more (concomitant or sequential) paraneoplastic endocrine syndromes is…

Posted in: cell 4 lung cancer 19 paraneoplastic 3 small cell 2 syndrome 7

Case Report

Acquired Hemophilia as a Paraneoplastic Manifestation of Gastrointestinal Stromal Tumor

Acquired hemophilia is a severe hemorrhagic diathesis characterized by the emergence of anti-factor VIII inhibiting antibodies. It is rarely seen in certain types of cancers as a paraneoplastic syndrome. The case of a 73-year-old patient who developed acquired hemophilia during the course of treatment for a gastrointestinal stromal tumor is…

Posted in: gastrointestinal 5 paraneoplastic 3 syndrome 7 tumor 6

Expired CME Article

Acute Radiation Syndrome: Assessment and Management

Primary care physicians may be unprepared to diagnose and treat rare, yet potentially fatal, illnesses such as acute radiation syndrome (ARS). ARS, also known as radiation sickness, is caused by exposure to a high dose of penetrating, ionizing radiation over a short period of time. The time to onset of…

Posted in: acute 7 radiation 4 radiation injury 2 syndrome 7

Case Report

Scimitar Syndrome: A Rare Cause of Dyspnea in Adults

Scimitar syndrome is a rare congenital malformation resulting in anomalous pulmonary venous return and lung malformations. Symptoms commonly develop in the first year of life, leading to diagnosis and surgical correction. In this case, the atypical presentation of scimitar syndrome in an adult woman with complaints of dyspnea on exertion…

Posted in: anomalous 2 pulmonary 2 syndrome 7

Case Report

Leukocytosis and Hypercalcemia: A Rare Combination of Paraneoplastic Features in Squamous Cell Penile Cancer

Penile cancer is very rare in North America and Europe, as compared with the rest of the world. Squamous cell carcinoma (SCC) accounts for more than 95% of the cancer type. Paraneoplastic syndrome (PNS), a clinical syndrome of nonmetastatic systemic effects that occurs in patients with malignant disease, is often…

Posted in: altered mental status 4 hypercalcemia 10 leukocytosis 2 paraneoplastic 3 syndrome 7
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