CME Course

Alpha-Gal Allergy as a Cause of Intestinal Symptoms in a Gastroenterology Community Practice

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Target Audience

Southern Medical Journal (SMJ) is an interdisciplinary, multi-specialty Journal, and articles span the spectrum of medical topics, providing timely, up-to-date information for primary care physicians and specialists alike. The SMJ enables physicians to provide the best possible care to patients in this age of rapidly changing modern medicine.  Therefore, the readers of the SMJ are an appropriate target for this article.

Goals and Objectives

Immunoglobulin E to alpha-gal may be an underrecognized but frequent cause of gastrointestinal tract symptoms in eastern North America in the habitat distribution of the Lone Star tick. In eastern North America Lone Star tick bites are the dominant mode of sensitization. Classically the alpha-gal syndrome manifests with urticaria, gastrointestinal symptoms, and/or anaphylaxis, but increasingly there are reports of isolated gastrointestinal symptoms without other common allergic manifestations. The objective of this retrospective study was to determine the frequency of IgE to alpha-gal in patients presenting with unexplained gastrointestinal symptoms to a community gastroenterology practice, and to evaluate the symptom response to the removal of mammalian products from the diet in alphagal– positive individuals. At the conclusion of the session, learners should be better prepared to:
Understand the epidemiology of Lone Star Tick bites and IgE mediated alpha-Gal food allergies.

  • Explore the possibility of alpha-GAL food allergies in patients with unexplained gastrointestinal symptoms.
  • Continue to survey the literature on this newly reported etiology for GI disorders.
  • Incorporate IgE alpha-GAL testing into your diagnostic evaluation of unexplained gastrointestinal symptoms.

Course Information

CME Release Date: March 3, 2021
Valid for credit through: March 2, 2022
Course type: CME Journal Article 
Estimated time of completion: 1 hour

Credits Available

Southern Medical Association is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Southern Medical Association designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AAPA: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

AANPCP: The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.

Healthcare Professionals
For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.  All healthcare professionals who are not MDs or DOs will receive a certificate of participation.

Instructions for Participation and Credit

This activity is designed to be completed within the time designated; learners should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period noted, following these steps:

  • Read the goals and objectives, accreditation information, and author disclosures.
  • Login in below to access the article in order to study the educational content and references.
  • Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score of 80%.
  • Complete the activity evaluation and attestation.

Upon successful completion of the test, evaluation and attestation, your certificate will be processed and emailed from customerservice@sma.org within approximately 1 hour. Credits will be archived for 6 years; at any point within this time period you may login to your account to print a duplicate copy of your certificate.

Disclosure of Relevant Financial Relationships

As an organization accredited by the ACCME, Southern Medical Association requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner that could create a conflict of interest.

Southern Medical Association encourages Speakers/Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.

The following individuals, unless otherwise notedhave no relevant financial relationships to disclose.

Manuscript Author(s):
Nathan E. Richards, MD
Robert D. Richards, Jr, MD 

Southern Medical Association/Southern Medical Journal Editorial Staff:
Steven T. Baldwin, MD, SMJ Editor-in-Chief
G. Richard Holt, MD, MSE, MPH, MABE, D BE, Interim SMJ Editor-in-Chief
Jennifer S. Price, MA, Managing Editor
Anita McCabe, Copyeditor

Course Materials

Course Content

(Click a lesson below to start the course).

This content is limited to qualifying members.

Existing members, please login first.

If you have an existing account please login now to access this course or view your purchase options.

Purchase this course now ($10)

Create a free account, then purchase access to this course.

Purchase a membership plan (fees vary)

Premium members can access all courses plus recieve many more benefits. View all membership plans and benefit packages.