Target Audience

This activity is designed for healthcare professionals including physicians, physician assistants, nurse practitioners, and allied healthcare professionals of all specialties.

Goals and Objectives

Approximately 10-30% of patients fail to have their BP controlled on three antihypertensive agents, one of which is a diuretic appropriate for the patient's kidney function. Reasons for this apparent lack of BP control to the new target of <130/80 mm Hg has to do with the inaccuracy of the office BP measurement itself, lack of adherence to drug therapy in 30-50% of patients, and inappropriate combinations of antihypertensive medications that do not complement each other’s mechanism of action. This course will review key secondary causes of hypertension including endocrine tumors, mineralocorticoid excess, and sleep apnea. A reasonable approach for those with resistant hypertension will be presented to further improve BP control rates in this high-risk population. At the conclusion of the session, learners should be better prepared to:

  • Describe the new definition of resistant hypertension;
  • Review the clinical workup of resistant hypertension including the importance of out-of-office or 24-hr ABPM to secure the diagnosis;
  • Recognize the importance of lifestyle modification and the evidence for the use of chlorthalidone over hydrochlorthiazide, and mineralocorticoid receptor antagonism (spironolactone or eplerenone) as a fourth drug to improve BP control in those with resistant hypertension.

Course Information

CME Release Date: January 8, 2018
Valid for credit through: January 8, 2019
Course type:  Video lecture

Credits Available

Southern Medical Association is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA PRA Category 1 Credits™

Southern Medical Association designates this enduring material for a maximum of  1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Healthcare Professionals

For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.  All healthcare professionals who are not MDs or DOs will receive a certificate of participation.

Instructions for Participation and Credit

To successfully earn credit, participants must complete the activity online during the valid credit period noted, following these steps:

  • Read the goals and objectives, accreditation information, and author disclosures.
  • View the educational video of the lecture.
  • Study the educational references.
  • Online, choose the best answer to each test question. Learners must receive a passing score of 80%.
  • Complete the activity evaluation and outcomes.

Upon successful completion of the test, evaluation and attestation, your certificate will be processed and emailed from [email protected] within approximately 1 hour. Credits will be archived for 6 years; at any point within this time period you may login to your account to print a duplicate copy of your certificate.

Click the Disclosure Tab above for Faculty Information

Disclosure of Relevant Financial Relationships

As an organization accredited by the ACCME, Southern Medical Association requires everyone who is in a position to control the content of an education activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines "relevant financial relationships" as financial relationships in any amount, occurring within the past 12 months, including financial relationships of a spouse or life partner that could create a conflict of interest.

Southern Medical Association encourages Speakers/Authors to identify investigational products or off-label uses of products regulated by the US Food and Drug Administration, at first mention and where appropriate in the content.

Jan Basile, MD

Dr. Basile earned his medical degree from the Medical College of Virginia in Richmond. He then completed his internship and residency at the Medical University of South Carolina in Charleston, where he was also Chief Resident. He is board certified in internal medicine and is a Fellow of the American College of Physicians (FACP), the American Society of Hypertension (FASH), and the American Heart Association (FAHA). For many years he served on the American Society of Hypertension (ASH) Board of Directors, and with the recent dissolution of ASH, he is serving within the AHA as Vice-Chair of Clinical Programs on the Council of Hypertension.

His many honors and awards include the Medical University of South Carolina School of Medicine Excellence in Teaching award, the Golden Apple award, and, in 2014, he was the first recipient of the SC Department of Health and Environmental Control Hypertension Physician of the Year award. He was President of the Southern Medical Association from 2008-2009.

Currently, he is Professor of Medicine at the Medical University of South Carolina (MUSC).  For the past 9 years he has volunteered at the Ralph H Johnson VA Medical Center. Prior to this, he spent 31 years at the VA while faculty at MUSC having retired as Chief of Primary Care in 2009.  He continues to direct the resistant hypertension clinic within the Seinsheimer Cardiovascular Health Program, a multi-risk factor lipid and resistant hypertension referral clinic at MUSC.

Dr. Basile’s research interests include outcome-based studies involving hypertension, lipid disorders, and diabetes. He has been involved in many large hypertension trials including the ALLHAT, ACCORD, ONTARGET, ACCOMPLISH, and SPRINT trials and most recently has concluded his participation in SPRINT-MIND, under the auspices of the National Heart, Lung, and Blood Institute. He was a contributing reviewer of the Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) and the 2017 ACC-AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.

Dr. Basile has published more than 300 original papers, abstracts, and book chapters, as well as a textbook, Hot Topics: Hypertension. He also is a contributing author for the hypertension section of "Up To Date".


  • Dr. Basile has the relevant financial relationships to disclose:
    • Research Grants: NHLBI (SPRINT), ReCor (RADIANCE)
    • Consultant: ReCor (RADIANCE), Up-to-Date (HTN Section)
    • Adjudication Committee: Medtronic Symplicity AF study
    • Steering Committee: Lilly (REWIND Diabetes Study)
  • Dr. Basile does not intend to discuss off-label or investigational uses of drugs, mechanical devices, biologics, or diagnostics not yet approved by the FDA for use in the United States.

Planning Committee
The following planning committee members have no relevant financial relationships to declare:
Jennifer Price, MA, SMA CME Program Manager

Course Materials


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