Dr. Basile earned his medical degree from the Medical College of Virginia in Richmond. He then completed his internship and residency at the Medical University of South Carolina in Charleston, where he was also Chief Resident. He is board certified in internal medicine and is a Fellow of the American College of Physicians (FACP), the American Society of Hypertension (FASH), and the American Heart Association (FAHA). For many years he served on the American Society of Hypertension (ASH) Board of Directors, and with the recent dissolution of ASH, he is serving within the AHA as Vice-Chair of Clinical Programs on the Council of Hypertension.

His many honors and awards include the Medical University of South Carolina School of Medicine Excellence in Teaching award, the Golden Apple award, and, in 2014, he was the first recipient of the SC Department of Health and Environmental Control Hypertension Physician of the Year award. He was President of the Southern Medical Association from 2008-2009.      

Currently, he is Professor of Medicine at the Medical University of South Carolina (MUSC).  For the past 9 years he has volunteered at the Ralph H Johnson VA Medical Center. Prior to this, he spent 31 years at the VA while faculty at MUSC having retired as Chief of Primary Care in 2009.  He continues to direct the resistant hypertension clinic within the Seinsheimer Cardiovascular Health Program, a multi-risk factor lipid and resistant hypertension referral clinic at MUSC.                       

Dr. Basile’s research interests include outcome-based studies involving hypertension, lipid disorders, and diabetes. He has been involved in many large hypertension trials including the ALLHAT, ACCORD, ONTARGET, ACCOMPLISH, and SPRINT trials and most recently has concluded his participation in SPRINT-MIND, under the auspices of the National Heart, Lung, and Blood Institute. He was a contributing reviewer of the Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) and the 2017 ACC-AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.

Dr. Basile has published more than 300 original papers, abstracts, and book chapters, as well as a textbook, Hot Topics: Hypertension. He also is a contributing author for the hypertension section of "Up To Date".