Case Report
Male Infertility and 21/1 Translocation
Abstract
ALTHOUGH THE ASSOCIATION OF OLIGOSPERMIA with autosomal chromosome aberrations has been well known since 1964, it is not often reported.1 In those cases which are reported. D/D translocations are most frequently involved, with D/G translocations next in frequency.2 Translocations involving the No. 1 chromosome are rare, though reported.3–8 Cases involving translocations between the No. 1 and No. 21 chromosomes also have been reported.7–8 In neither of these reports, however, was there an association with male infertility or azospermia, and mental retardation was a feature of both reports. It is our belief that the case presented here is the first reported involving infertility in a male with an A/G (21/1) translocation in the absence of mental retardation.This content is limited to qualifying members.
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