Case Report

Neonatal Lupus in Twins

Authors: NAOMI LAWRENCE MD, CAREY A. BLIGARD MD, JAMES STORER MD, MARY LOU COURREGE MD

Abstract

NEONATAL LUPUS is a rare syndrome. In the approximately 100 cases reported in the literature, the syndrome has been characterized by cutaneous lupus erythematosus (LE) lesions, systemic disease such as hepatosplenomegaly and Coombs'-positive hemolytic anemia, and cardiac conduction defects.1 In this report, we describe the clinical and serologic features of NLE in twins, and present the HLA haplotypes of the parents and infants. We compare our findings with other twin cases and other cases in which HLA haplotyping was done. We have also reviewed the literature to present a complete picture of the rapidly evolving understanding of this disease.

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References