Genetics design.

Genetic variations found associated with high blood pressure.

Results from several studies pertaining to the genetics of blood pressure were published in the September 12, 2016 issue of Nature Genetics. These studies lead to new approaches for the treatment of hypertension.

More than 340,000 population samples were used to look for genetic variations that might be used to regulate blood pressure.

One study,  "The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals" analyzed Cardio-Metabochip microarray data to identify regions of the genome associated with blood pressure. Although no predominant variation was found, researchers identified 17 new regions of the genome that may potentially be used to help control blood pressure.

Another study, "Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci" performed a meta-analysis of Human Exome Chip data and found 31 new blood pressure regions and verified other regions that have been strongly linked to heart disease.

A third study, "Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension" identified 30 new hypertension-associated genetic regions and provided new insight into the treatment of hypertension.

Combined, these three studies help expand our understanding of genetic components related to blood pressure  and provided us with a stepping off point for further study.

“This is very exciting research and gets us one step closer toward a better understanding of the complexities of this devastating disease.

Patients and providers must continue to remain focused on identifying and treating hypertension with interventions that are proven to reduce the risk of complications from this widely prevalent, potentially debilitating disease.”

Bryan N. Batson, MD
Director of Hattiesburg Hypertension Clinic

References:

Tianna Hicklin, Ph.D. National Institute of Health (NIH). The genetics of blood pressure.
https://www.nih.gov/news-events/nih-research-matters/genetics-blood-pressure. Published September 20, 2016. Accessed October 3, 2016.

National Center for Biotechnology Information. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
https://www.ncbi.nlm.nih.gov/pubmed/27618452. Published September 12, 2016. Accessed October 3, 2016.

National Center for Biotechnology Information. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
https://www.ncbi.nlm.nih.gov/pubmed/27618448. Published September 12, 2016. Accessed October 3, 2016.

National Center for Biotechnology Information. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/27618447.  Published September 12, 2016. Accessed October 3, 2016.

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