Review Article

Acute Lymphocytic Leukemia after Fulminant Varicella Associated with Severe Neutropenia: In Reply

Authors: Rajasekharan P. Warrier, MD, FAAP


In Reply:

Dr. Moiz's comments on the role of bone marrow biopsy are appropriate. Bilateral posterior iliac crest biopsies were performed and reviewed by the pathology department. The sections showed marked hypocellularity but did not show any evidence of acute lymphoblastic leukemia. Bone marrow aspirate, biopsy, and chromosomal studies of the initial marrow were not suggestive of acute lymphoblastic leukemia. Immunophenotyping showed a slight increase in early pre-B cells in the original marrow, as my coauthors and I described in our report. 1

Rajasekharan P. Warrier, MD, FAAP

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1. Helft DA, Correa H, Rojas P, Warrier RP. Acute lymphocytic leukemia after fulminant varicella associated with severe neutropenia. South Med J 2002; 95: 1074–1075.