Letter to the Editor

Adult T-cell Lymphoma with HTLV-I and HTLV-II Infection

Authors: Ramachandran Venkitaraman, MD, DM, FRCR, Tenali G. Sagar, MD, DM, Mathew K. George, MD, DM


To the Editor:

Human T-cell lymphotrophic viruses (HTLV), retroviruses classified as HTLV-I and HTLV-II, predominantly infect CD4 and CD8 T-cells respectively. HTLV-I causes adult T-cell leukemia/lymphoma (ATL), while the relation of HTLV-II to causation of ATL is unclear.1 We present the case of a 48-year-old male patient with cutaneous lymphoma of T-cell origin and paraparesis, who was found to be infected with HTLV-I and HTLV-II.

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1. Manns A. Natural history of HTLV-I infection: relationship to leukemogenesis. Leukemia 1993;7(Suppl 2):S75–77.
2. Pancake BA, Zucker-Franklin D, Coutavas EE. The cutaneous T cell lymphoma, mycosis fungoides, is a human T cell lymphotropic virus-associated disease. A study of 50 patients. J Clin Invest1995;95:547–554.
3. Guitart J. HIV-1 and an HTLV-II-associated cutaneous T-cell lymphoma. N Engl J Med 2000;343:303–304.
4. Zucker-Franklin D, Pancake BA. The role of human T-cell lymphotropic viruses (HTLV-I and II) in cutaneous T-cell lymphomas. Semin Dermatol 1994;13:160–165.
5. Nishimura Y, Yoshiki K, Yamaguchi K, et al. [Seropositivity of anti-HTLV-II antibodies in patients with HTLV-I-associated myelopathy and adult T-cell leukemia] Rinsho Byori 1991;39:1351–1352.
6. Caterino-de-Araujo A, Favero A, de los Santos-Fortuna E, et al. HTLV-I/HTLV-II coinfection in an AIDS patient from São Paulo, Brazil. AIDS Res Hum Retroviruses 2000;16:715–719.
7. Jimbow K, Jewell LD. Lymphoid proliferation and lymphoma associated with human retroviruses (HTLV and HIV). Int J Dermatol 1991;30:605–613.
8. Whittaker SJ, Ng YL, Rustin M, et al. HTLV-1-associated cutaneous disease: a clinicopathological and molecular study of patients from the U.K. Br J Dermatol 1993;128:483–492.