Review Article

Carcinoma With Unknown Primary Tumor (CUP Syndrome)

Authors: MICHAEL J. NISSENBLATT MD

Abstract

ABSTRACTApproximately 10% of adenocarcinomas are first seen without a detectable primary tumor. The clinical state that results when a metastatic deposit is more symptomatic than its primary I have termed the CUP (carcinoma unknown primary) syndrome. By definition CUP tumors are incurable by current treatment but their management often includes extensive and expensive efforts to detect the organ of origin. This article stresses the pitfalls in clinical diagnosis and management and outlines an empiric, palliative approach to therapy.

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References