Concomitant Graves Hyperthyroidism with Thyrotrophin-Secreting Pituitary Adenoma
The relationship of autoimmune thyroid disease and TSH-producing pituitary tumor is rarely found. We report two patients with hyperthyroidism, a 27-year-old man and a 28-year-old woman, who were diagnosed with Graves hyperthyroidism with elevated free thyroxine (FT4), suppressed TSH and positive thyrotropin receptor autoantibodies. After treatment with antithyroid drugs, FT4 did not return to normal, and serum TSH levels were found to be above-normal range. Pituitary tumors were subsequently found via pituitary magnetic resonance imaging (MRI). We suggest that Graves hyperthyroidism concomitant with TSH-producing pituitary tumor be kept in mind, as it may confuse the therapeutic course of hyperthyroidism and make it more complicated.
* A relationship between autoimmune thyroid disease and TSH-producing pituitary tumor is rare.
* Two patients with concomitant Graves hyperthyroidism and pituitary tumors found during a therapeutic course of antithyroid medication are presented.
* Graves hyperthyroidism concomitant with TSH-producing pituitary tumors should be kept in mind, as it may complicate the therapeutic course of hyperthyroidism.
This content is limited to qualifying members.
If you have an existing account please login now to access this article or view your purchase options.
Create a free account, then purchase this article to download or access it online for 24 hours.
Create a free account, then purchase a subscription to get complete access to all articles for a full year.