Letter to the Editor

Continuous Venovenous Hemodiafiltration in Severe Metabolic Acidosis Secondary to Ethylene Glycol Ingestion

Authors: Christopher Gilbert, DO, Michael Baram, MD, FCCP, Paul E. Marik, MD, FCCP


To the Editor:

Ethylene glycol (EG) poisoning is uncommon, yet if unrecognized, potentially fatal. Treatment options for EG toxicity include correction of metabolic acidosis, fomepizole, hemodialysis, and supportive care.1 We present a unique case of severe metabolic acidosis secondary to EG and use of continuous venovenous hemodiafiltration (CVVHDF) over traditional hemodialysis, secondary to significant cerebral edema.

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1. Abramson S, Singh AK. Treatment of the alcohol intoxications: ethylene glycol, methanol and isopropanol. Curr Opin Nephrol Hypertens 2000;9:695–701.
2. Hylander B, Kjellstrand CM. Prognostic factors and treatment of severe ethylene glycol intoxication. Intensive Care Med 1996;22: 546–552.
3. Mégarbane B, Borron SW, Baud FJ. Current recommendations for treatment of severe toxic alcohol poisonings. Intensive Care Med 2005;31:189–195.
4. Chang MY, Fang JT, Chen YC, et al. Continuous venovenous haemofiltration in hyperammonaemic coma of an adult with non-diagnosed partial ornithine transcarbamylase deficiency. Nephrol Dial Transplant 1999;14:1282–1284.
5. Davenport A, Will EJ, Davison AM. Early changes in intracranial pressure during haemofiltration treatment in patients with grade 4 hepatic encephalopathy and acute oliguric renal failure. Nephrol Dial Transplant 1990;5:192–198.