Case Report

Eosinophilic Pleural Effusion, Peripheral Eosinophilia, Pleural Thickening, and Hepatosplenomegaly in Sarcoidosis

Authors: Evaggelos Vafiadis, MD, Maria S. Sidiropoulou, MD, Vasilios Voutsas, MD, Theodoros L. Giannopoulos, MD, Fotis Iordanidis, MD, Pandora Christaki, PhD, Panagiotis Palladas, MD


In this atypical case of sarcoidosis with an unusual combination of clinical and laboratory findings, a 32-year-old male presented with a 3-month history of thoracic pain complicated with dyspnea. Laboratory tests, chest radiography, and CT scans of the chest and abdomen revealed eosinophilia of pleural effusion and blood, pleural thickening, hepatosplenomegaly, and bronchiolitis obliterans. In cases such as this, in which pleural fluid eosinophilia is accompanied by peripheral eosinophilia and splenohepatomegaly, underlying malignancies such as Hodgkin lymphoma should be ruled out. A biopsy of the mediastinal lymph nodes suggested noncaseating epithelioid granulomas, characteristic of sarcoidosis. The patient underwent prednisolone therapy for 1 year and is doing well 2 years after initial diagnosis.

Key Points

* A 32-year-old male had laboratory tests, chest radiograph, and CT scans that revealed eosinophilia of pleural effusion and had blood, pleural thickening, hepatosplenomegaly, and bronchiolitis obliterans.

* Differential diagnosis mainly included lymphoma and sarcoidosis.

* Biopsy of mediastinal lymph nodes was finally performed to determine a definite diagnosis and suggested noncaseating epithelioid granulomas characteristic of sarcoidosis.

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