Abstract

PSEUDOMEMBRANOUS ENTEROCOLITIS is a recognized complication resulting from the use of diverse kinds of antibiotics. Recent reports have noted this development following the use of lincomycin and a related antibiotic, clindamycin.1–4 The following report describes a fatal case of colitis associated with an antibiotic program which included clindamycin. Our patient with mild classical hemophilia developed a high level factor VIII inhibitor after major surgery and was successfully managed with a plasma concentrate, activated prothrombin complex (Auto IX*).5 Subsequently he deyeloped an antibiotic-associated hemorrhagic ulcerative colitis. The combination of a severe hemorrhagic colitis coupled with a factor VIII inhibitor proved to be lethal.