Case Report

Granulocyte Colony Stimulating Factor in the Treatment of Alcohol Abuse, Leukopenia, and Pneumococcal Sepsis

Authors: EDWIN W. GRIMSLEY MD

Abstract

ABSTRACTA 32-year-old woman was admitted with alcoholism, leukopenia, and pneumococcal sepsis (ALPS). Standard treatment consists of antibiotics, vitamin replacement, and intensive care unit support. Even with this treatment, the mortality rate is exceedingly high. In addition to standard therapy, this patient received subcutaneously 300 μg granulocyte colony stimulating factor (G-CSF) daily. Initial white blood cell count was 700 μL; by day 4 it had increased to 11,400 μL. She had a prolonged hospital course but was discharged in good condition 6 weeks after admission. G-CSF may be warranted in treating ALPS.

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References