Primary Article

Myelodysplastic Syndrome: Identification in the Routine Hematology Laboratory

Authors: EDWARD S. RAPPAPORT MD, BARBARA HELBERT MT (ASCP), DANIEL J. LADD MD, ARTHUR A. TROWBRIDGE MD

Abstract

ABSTRACT: The Coulter S+IV electronically generates an automated white blood cell differential which counts 10,000+ cells per sample, separating lymphocytes, mononuclear cells, and granulocytes. In patients with preleukemic or so-called myelodysplastic syndromes, the histograms are consistently abnormal. CBCs of five patients demonstrate the variable features of myelodysplasia involving abnormal monocytosis, neutropenia, thrombocytopenia, and macro-ovalocytic anemias. The histogram analysis of white blood cells is a rapid, economic way of alerting the hematologist to a possible diagnostic problem in the elderly patient population.

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References