Original Article

Objectively Measured Physical Activity and All-Cause Mortality Among Cancer Survivors: National Prospective Cohort Study

Authors: Paul D. Loprinzi, PhD, Allison Nooe, BS

Abstract

Objective: The understanding of the effects of physical activity on all-cause mortality among cancer survivors is limited. We attempted to draw a relation between physical activity and survival among those with a diagnosis of cancer.

Methods: Data from the 2003–2006 National Health and Nutrition Examination Survey was used, with follow-up through 2011. A total of 515 adult cancer survivors wore an accelerometer for ≥4 days.

Results: After adjusting for age, sex, race/ethnicity, poverty level, cotinine, C-reactive protein, body mass index, and comorbid illness, participants had a 15% reduced hazard rate (hazard rate 0.85, 95% confidence interval 0.73–0.99, P < 0.001) for every 60-minute/day increase in physical activity.

Conclusions: Physical activity may have a protective effect on survival among cancer survivors.
Posted in: Medical Oncology46

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References

1. Loprinzi PD, Cardinal B, Smit E, et al. Physical activity and breast cancer risk. J Exerc Sci Fit 2012;10:1-7.
2. Loprinzi PD, Lee H. Rationale for promoting physical activity among cancer survivors: literature review and epidemiologic examination. Oncol Nurs Forum 2014;41:117-125.
3. Gonçalves AK, Dantas Florencio GL, Maisonnette de Atayde Silva MJ, et al. Effects of physical activity on breast cancer prevention: a systematic review. J Phys Act Health 2014;11:445-454.
4. Wolin KY, Tuchman H. Physical activity and gastrointestinal cancer prevention. Recent Results Cancer Res 2011;186:73-100.
5. Liu Y, Hu F, Li D, et al. Does physical activity reduce the risk of prostate cancer? A systematic review and meta-analysis. Eur Urol 2011;60:1029-1044.
6. Davies NJ, Batehup L, Thomas R. The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature. Br J Cancer 2011;105( suppl 1 ):S52-S73.
7. Loprinzi PD, Cardinal BJ, Winters-Stone K, et al. Physical activity and the risk of breast cancer recurrence: a literature review. Oncol Nurs Forum 2012;39:269-274.
8. Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol 2014;25:1293-1311.
9. Shephard RJ. Limits to the measurement of habitual physical activity by questionnaires. Br J Sports Med 2003;37:197-206.
10. Loprinzi PD, Walker JF, Lee H. Association between physical activity and inflammatory markers among U.S. adults with chronic obstructive pulmonary disease. Am J Health Promot 2014;29:81-88.
11. Streckmann F, Kneis S, Leifert JA, et al. Exercise program improves therapy-related side-effects and quality of life in lymphoma patients undergoing therapy. Ann Oncol 2014;25:493-499.
12. San Juan AF, Fleck SJ, Chamorro-Vina C, et al. Early-phase adaptations to intrahospital training in strength and functional mobility of children with leukemia. J Strength Cond Res 2007;21:173-177.
13. Travier N, Velthuis MJ, Steins Bisschop CN, et al. Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial. BMC Med 2015;13:121.
14. Ostir GV, Berges IM, Kuo YF, et al. Mobility activity and its value as a prognostic indicator of survival in hospitalized older adults. J Am Geriatr Soc 2013;61:551-557.
15. Loprinzi PD, Lee H, Cardinal BJ. Objectively measured physical activity among US cancer survivors: considerations by weight status. J Cancer Surviv 2013;7:493-499.
16. Loprinzi PD, Cardinal BJ. Effects of physical activity on common side effects of breast cancer treatment. Breast Cancer 2012;19:4-10.