Case Report

Pregnancy Complicated by Plasminogen Activator Inhibitor Type 1 Deficiency

Authors: Charnetta Smith, MD, Yvonne S. Thornton, MD, MPH

Abstract

We present the case of a patient with a history of hemorrhage following prior surgery whose pregnancy was complicated by plasminogen activator inhibitor type 1 deficiency. To our knowledge, this is the first reported case of a pregnancy complicated by plasminogen activator inhibitor type 1 (PAI-1) deficiency.

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References

1. Mehta R, Shapiro AD. Plasminogen activator inhibitor type 1 deficiency. Haemophilia 2008;14:1255–1260.
 
2. Santamaría A, Borrell M, Mateo J. What is the clinical impact of low plasminogen activator inhibitor-1 (PAI-1) activity? A case report and study of the incidence of low PAI-1 antigen in a healthy population. J Thromb Haemost 2007;5:1565–1566.
 
3. Kruithof EK, Tran-Thang C, Gudinchet A, et al. Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors. Blood 1987;69:460–466.
 
4. Glueck CJ, Kupferminc MJ, Fontaine RN, et al. Genetic hypofibrinolysis in complicated pregnancies. Obstet Gynecol 2001;97:44–48.