Letter to the Editor
Response to "Nephrolithiasis: Evaluation and Management"
Abstract
To the Editor: We would like to thank the author for his valuable comments on our paper "Nephrolithiasis: Evaluation and Management."1 He emphasized the importance of detailed medication history in accurate identification of kidney stone sources. Drug-induced stones comprise 1% to 2% of all kidney stones and occur more often during high-dose or long-term treatments, especially in patients with risk factors in relation to urine pH and urine output.2 More than 40 drugs and substances have been linked to nephrolithiasis. Main substances that were identified in stones over the past decade were indinavir monohydrate (31.4%), triamterene (11.1%), sulfonamides (10.5%) and amorphous silica (4.5%).2 The main drugs involved in the nucleation and growth of stones were calcium and vitamin D supplementation (15%) and long-term treatment with carbonic anhydrase inhibitors (8%).2This content is limited to qualifying members.
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