Original Article

Cirrhosis Following Prolonged Treatment of Psoriasis with Methotrexate Orally

Authors: J. A. ROBESON, MD, J. SPENNEY, MD, B. I. HIRSCHOWITZ, MD

Abstract

The use of this drug in long-term management of psoriasis has emphasized its hepatotoxicity. The present case report indicates that even low dose intermittent but long-term treatment may produce hepatic cirrhosis. This bears out the warnings issued by the FDA and the manufacturer concerning the use of this drug in the management of psoriasis.

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References