Dr. Jaffe is the Senior Vice President of the Resolve to Save 100 Million Lives Cardiovascular Health Initiative, an initiative of Vital Strategies, and a Senior Physician of the Permanente Medical Group in South San Francisco, California.

Dr. Jaffe joined Kaiser Permanente in 1993, and in 2000 he led the establishment of the Kaiser Permanente Northern California Hypertension Program. In 2004 he led the creation of the Kaiser Permanente Northern California Prevent Heart Attacks and Strokes Everyday (PHASE) program which designs, implements, and evaluates the delivery of cardiovascular preventive services to high risk individuals with diabetes or cardiovascular disease.

From 2009 to 2017 he was the Clinical Leader of the Kaiser National Integrated Cardiovascular Health Guideline Team.  From 2013-2015 he served as a consultant to the Centers for Disease Control (CDC) for the Global Standardization Treatment Project and from 2015 - 2017 he was a technical advisor for the World Health Organization/PanAmerican Health Organization Hypertension Program. In September 2017, he joined Resolve to Save Lives to Save Lives as the Senior Vice President of Cardiovascular Health, with the goal of preventing 100 million deaths from cardiovascular disease in low and middle-income countries.

Dr. Jaffe attended the University of California at Berkeley and the Baylor College of Medicine in Houston, Texas.  He completed residency at the University of California, San Diego, and did his Endocrinology fellowship at the University of California, San Francisco. He is an Associate Clinical Professor of Medicine at the University of California, San Francisco, Medical School. He is board certified in Internal Medicine and in Diabetes, Endocrinology, and Metabolism.