Editorial

Anticonvulsant Hypersensitivity Syndrome and Drug-Induced Hepatic Injury

Authors: Reamer L. Bushardt PharmD, PA-C

Abstract

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References

References1. Ouellet G, Tremblay L, Marleau D. Fulminant hepatitis induced by lamotrigine. South Med J 2009;102:82–84.OuelletG]]TremblayL]]MarleauDFulminant hepatitis induced by lamotrigine.South Med J200910282-842. Mason M. Anticonvulsant hypersensitivity syndrome: recognizing the signs and symptoms. Resident Staff Physician 2007;53:16. Available at: http://www.residentandstaff.com/issues/articles/2007-03_11.asp. Accessed November 10, 2008.3. Morkunas AR, Miller MB. Anticonvulsant hypersensitivity syndrome. Crit Care Clin 1997;13:727–739.MorkunasAR]]MillerMBAnticonvulsant hypersensitivity syndrome.Crit Care Clin199713727-7394. Kaur S, Sarkar R, Thami GP, et al. Anticonvulsant hypersensitivity syndrome. Pediatr Dermatol 2002;19:142–145.KaurS]]SarkarR]]ThamiGP&etal;Anticonvulsant hypersensitivity syndrome.Pediatr Dermatol200219142-1455. Tennis P, Stern RS. Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study. Neurology 1997;49:542–546.TennisP]]SternRSRisk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study.Neurology199749542-5466. Brown CE, Smith GD, Coniglione T. Anticonvulsant hypersensitivity: an unfortunate case of triple exposure to phenytoin. J Fam Pract 1997;45:434–437.BrownCE]]SmithGD]]ConiglioneTAnticonvulsant hypersensitivity: an unfortunate case of triple exposure to phenytoin.J Fam Pract199745434-4377. Vittorio CC, Muglia JJ. Anticonvulsant hypersensitivity syndrome. Arch Intern Med 1995;155:2285–2290.VittorioCC]]MugliaJJAnticonvulsant hypersensitivity syndrome.Arch Intern Med19951552285-22908. Erwin MB, Barden A. Anticonvulsant hypersensitivity syndrome. J Crit Illn 2001;16:71–76.ErwinMB]]BardenAAnticonvulsant hypersensitivity syndrome.J Crit Illn20011671-769. Manders SM. Serious and life-threatening drug eruptions. Am Fam Physician 1995;51:1865–1872.MandersSMSerious and life-threatening drug eruptions.Am Fam Physician1995511865-187210. Ostapowicz G, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002;137:947–954.OstapowiczG]]FontanaRJ]]SchiodtFV&etal;Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.Ann Intern Med2002137947-95411. Williams R. Classification, etiology, and considerations of outcome in acute liver failure. Semin Liver Dis 1996;16:343–348.WilliamsRClassification, etiology, and considerations of outcome in acute liver failure.Semin Liver Dis199616343-34812. Bjornsson E, Olsson R. Suspected drug-induced liver fatalities reported to the WHO database. Dig Liver Dis 2006;38:33–38.BjornssonE]]OlssonRSuspected drug-induced liver fatalities reported to the WHO database.Dig Liver Dis20063833-38