Review Article
Central Nervous System Infections in Transplant Recipients by Cladophialophora bantiana
Abstract
Cladophialophora bantiana, a dematiaceous fungus, is an uncommon pathogenic organism originally thought to more commonly affect immunocompetent patients. Increasing numbers of reports, however, describe the organism affecting immunocompromised patients. Like all dematiaceous fungi, Cladophialophora can be recognized in histopathologic sections by the golden-brown coloration in the walls of the hyphae. Of all the dematiaceous fungi, Cladophialophora bantiana demonstrates the most neurotropism, which is responsible for increasing recognition of this fungus as the causative agent in brain abscesses in transplant patients. We describe one patient with a liver transplant and another with a double lung transplant, both of whom developed cerebral abscesses caused by this organism, and review the reported literature.
Key Points
* Cladophialophora bantiana is the most common neurotropic dematiaceous fungus.
* Originally thought to be more common in immunocompetent patients, Cladophialophora bantiana is increasingly recognized in patients with immunosuppression.
* This pigmented fungus should be suspected in solid organ transplant patients with brain abscesses.
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