Letter to the Editor

Classical Nodular Sclerosis Hodgkin Lymphoma Presenting with Central Nervous System Disease

Authors: Akshay K. Gupta, MD, Dennis Meisner, MD, Neetu Talreja, Ryan Smith, MD, Steven H. Swerdlow, MD

Abstract

To the Editor:


The incidence of primary classical nodular sclerosis (CNS) lymphoma has increased significantly over the last 2 decades. Non-Hodgkin lymphomas (NHL) of B-cell origin account for the majority of these neoplasms. In contrast to NHL, CNS involvement by Hodgkin lymphoma (HL) is exceedingly rare. In a large clinical series of 2185 patients of HL, CNS involvement was seen in only 0.2% cases.1 All of these cases with CNS involvement were seen at relapse, along with disseminated systemic disease. Presentation of HL with a primary intracranial lesion is extremely rare, with only sporadic cases reported in the literature. We report the following case of biopsy proven Classical Nodular Sclerosis Hodgkin lymphoma presenting in a young male with simultaneous intracranial and spinal involvement, along with nodal disease.

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References

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