Invited Commentary

Commentary on "Low 25-Hydroxyvitamin D Levels in Children With Spina Bifida"

Authors: B. Louise Giles, MD

Abstract

Vitamin D deficiency has received attention during the past decade as a contributing factor in many diseases, ranging from asthma to venous thromboembolism.1 The main manifestation of vitamin D deficiency is osteomalacia and development of rickets.2,3 As such, it would make sense that those at risk of fractures (eg, osteoporosis) may have vitamin D deficiency as a contributing factor.2

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References

1. Reid IR. What diseases are causally linked to vitamin D deficiency? Arch Dis Child 2015. [Epub ahead of print].
 
2. Bischoff-Ferrari H. Vitamin D--from essentiality to functionality. Int J Vitam Nutr Res 2012;82:321-326.
 
3. Abrams SA. Dietary guidelines for calcium and vitamin D: a new era. Pediatrics 2011;127:566-568.
 
4. Vitamin D supplementation: recommendations for Canadian mothers and infants. Paediatr Child Health 2007;12:583-598.
 
5. Marreiros H, Loff C, Calado E. Osteoporosis in paediatric patients with spina bifida. J Spinal Cord Med 2012;35:9-21.
 
6. Baum M, Stein D, Feldman H, et al. Vitamin D deficiency in children with spina bifida. Paper presented at: World Congress on Spina Bifida Research and Care; March 11-14, 2012; Las Vegas.
 
7. Martinelli V, Dell’Atti C, Ausili E, et al. Risk of fracture prevention in spina bifida patients: correlation between bone mineral density, vitamin D, and electrolyte values. Childs Nerv Syst 2015;31:1361-1365.
 
8. Mazur LJ, Wilsford LD, Rosas L, et al. Low 25-hydroxyvitamin D levels in children with spina bifida. South Med J 2016;109:31-35.