Editorial

Cutaneous Carcinoma with Mixed Histology

Authors: Conway C. Huang, MD

Abstract

It is accepted that different histologic subtypes of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) exist, and that these subtypes differ in their biologic aggressiveness. In this issue of theJournal, Cohen and Nelson make a convincing argument that mixed histology BCCs and SCCs could represent a cause of recurrence when only the more benign histologic component is biopsied, thus causing the physician to select a treatment modality that is not sufficient to remove the more aggressive histologic component of the tumor.

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References

1. Swetter SM, Yaghmai D, Egbert BM. Infiltrative basal cell carcinoma occurringin sites of biopsy-proven nodular basal cell carcinoma. J Cutan Pathol 1998;25:420–425.
 
2. Freeman RG, Duncan WC. Recurrent skin cancer. Arch Dermatol 1973;107:395–399.
 
3. Sexton M, Jones DB, Maloney ME. Histologic pattern analysis of basal cell carcinoma. J Am Acad Dermatol 1990;23:1118–1126.
 
4. Jones MS, Maloney ME, Billingsley EM. The heterogeneous nature of in vivo basal cell carcinoma.Dermatol Surg 1998;24:881–884.
 
5. Cook J, Zitelli JA. Mohs micrographic surgery: A cost analysis. J Am Acad Dermatol 1998;39:698–703.
 
6. Bialy TL, Whalen J, Veledar E, et al. Mohs micrographic surgery versus traditional surgical excision.Arch Dermatol 2004;140:736–742.