Case Report

Epidermodysplasia Verruciformis

Authors: Joshua E. Lane, MD, Paul H. Bowman, MD, David J. Cohen, MD

Abstract

Epidermodysplasia verruciformis is an uncommon cutaneous entity characterized by persistent human papillomavirus infection. A defect in cell-mediated immunity is the suggested causative factor. Numerous specific human papillomavirus types have been detected in this disease. Multiple nonmelanoma skin cancers are commonly seen in such patients; thus, early diagnosis is beneficial.

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References

1. Lewandowsky F, Lutz W. Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis). Arch Dermatol Syphilol 1922; 141: 193–203.
2. Jacyk WK, deVilliers EM. Epidermodysplasia verruciformis in Africans. Int J Dermatol 1993; 32: 806–810.
3. Jablonska S, Majewski S. Epidermodysplasia verruciformis: Immunological and clinical aspects. Curr Top Microbiol Immunol 1994; 186: 157–175.
4. Lutzner MA. Epidermodysplasia verruciformis: An autosomal recessive disease characterized by viral warts and skin cancer. Bull Cancer 1978; 65: 169–182.
5. Harris AJ, Purdie K, Leigh IM, Proby C, Burge S. A novel human papillomavirus identified in epidermodysplasia verruciformis. Br J Dermatol 1997; 136: 587–591.
6. Majewski S, Skopinska-Rozewska E, Jablonska S, Wasik M, Misiewicz J, Orth G. Partial defects of cell-mediated immunity in patients with epidermodysplasia verruciformis. J Am Acad Dermatol 1986; 15: 966–973.
7. Cooper KD, Androphy EJ, Lowy DR, Katz SI. Antigen presentation and T-cell activation in epidermodysplasia verruciformis. J Invest Dermatol 1990; 94: 769–776.
8. Haftek M, Jablonska S, Szmanczyk J, Jarzabek-Chorzelska M. Langerhans cells in epidermodysplasia verruciformis. Dermatologica 1987; 174: 173–179.
9. Yutsudo M, Hakura A. Human papillomavirus type 17 transcripts expressed in skin carcinoma tissue of a patient with epidermodysplasia verruciformis. Int J Cancer 1987; 39: 586–589.
10. Deau MC, Favre M, Orth G. Genetic heterogeneity among human papillomaviruses (HPV) associated with epidermodysplasia verruciformis: Evidence for multiple allelic forms of HPV5 and HPV8 E6 genes. Virology 1991; 184: 492–503.
11. Astori G, Lavergne D, Benton C, Hockmayr B, Egawa K, Garbe C, et al. Human papillomaviruses are commonly found in normal skin of immunocompetent hosts. J Invest Dermatol 1998; 110: 752–755.
12. Steger G, Olsewsky M, Stockfleth E, Pfister H. Prevalence of antibodies to human papilloma virus type in the human sera. J Virol 1990; 64: 4399–4406.
13. Androphy EJ, Dvoretsky I, Lowy DR. X-linked inheritance of epidermodysplasia verruciformis: Genetic and virologic studies of a kindred. Arch Dermatol 1985; 121: 864–868.
14. Karrer S, Szeimies RM, Abels C, Wlotzke U, Stolz W, Landthaler M. Epidermodysplasia verruciformis treated using topical 5-aminoaevulinic acid photodynamic therapy. Br J Dermatol 1999; 140: 935–938.

Only when we learn to see the invisible, Will we learn to do the impossible. —Frank Gaines