Case Report

Ezetimibe-induced Acute Pancreatitis

Authors: Imran Ahmad, MD, Edward Ruby, MD, Harris Usman, MD, Mateen Hotiana, MD, Mehnaz Hussain, MD, Fahd Rahman, MD

Abstract

Ezetimibe is a lipid-lowering agent that inhibits the intestinal absorption of cholesterol and other related phytosterols. It is used alone or in combination with other lipid-lowering agents in the treatment of various forms of hypercholesterolemia. Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.


Key Points


* Drugs are an important, but rare, cause of acute pancreatitis.


* Ezetimibe, a lipid-lowering drug, can cause acute pancreatitis.


* Identification and discontinuation of the offending drug is of great importance in cases of drug-induced acute pancreatitis.

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References

1. Lankisch PG, Lowenfels AB, Maisonneuve P. What is the risk of alcoholic pancreatitis in heavy drinkers? Pancreas 2002;25:411–412.
 
2. Venneman NG, Buskens E, Besselink MG, et al. Small gallstones are associated with increased risk of acute pancreatitis: potential benefits of prophylactic cholecystectomy? Am J Gastroenterol 2005;100:2540–2550.
 
3. Toskes PP. Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 1990;19:783–791.
 
4. Brandwein SL, Sigman KM. Case report: milk-alkali syndrome and pancreatitis. Am J Med Sci 1994;308:173–176.
 
5. Ruenzi M, Layer P. Drug-associated pancreatitis: facts and fiction. Pan-creas 1996;13:100–109.
 
6. Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Saf 1996;14:406–423.
 
7. McArthur KE. Review article: drug-induced pancreatitis. Aliment Pharmacol Ther 1996;10:23–28.
 
8. Mallory A, Kern F Jr. Drug-induced pancreatitis: a critical review. Gastroenterology 1980;78:813–820.
 
9. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239–245.
 
10. Lankisch PG, Droege M, Gottesleben F. Drug-induced acute pancreatitis: incidence and severity. Gut 1995;37:565–567.