Case Report

Four Primary Tumors of Lung, Bladder, Prostate, and Breast in a Male Patient

Authors: Zaher K. Otrock, MD, Rami A.R. Mahfouz, MD, Ziad M. Salem, MD

Abstract

We present a very rare case of quadruple cancers in a 65-year-old male patient. It is a case of both synchronous and metachronous primary malignant neoplasms occurring in four different organs. Immunohistochemical stains showed tumor cell nuclei to be negative for p53 over-expression. To our knowledge, this is the first documented case with this combination of primary tumors. The tumors included an adenosquamous cell carcinoma of the lung, transitional cell carcinoma of the urinary bladder, and adenocarcinomas of the prostate and the breast. We also review the medical literature for the possible causes of multiple primary malignant neoplasms.


Key Points


* The diagnosis of multiple primary neoplasms is made following definite criteria.


* The incidence of multiple primary neoplasms is influenced by environmental, genetic, or some combination of factors.


* Patients with multiple primary neoplasms should be closely monitored as they have a high incidence of other cancers or recurrence of their primaries.

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