The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.

SMJ // Article

Case Report

Inclusion Body Myositis Associated with Celiac Sprue and Idiopathic Thrombocytopenic Purpura

Authors: Sandra F. Williams, MD, Betty A. Mincey, MD, Kenneth T. Calamia, MD

Abstract

We report an unusual case of a 51-year-old woman with inclusion body myositis associated with celiac sprue and idiopathic thrombocytopenic purpura. We propose that the presence of all three disorders together suggests that they may share an interrelated immune mechanism.

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References

1. Mikol J, Engel AG. Inclusion body myositis, in Engel A, Franzini-Armstrong C (eds): Myology: Basic and Clinical. New York, McGraw-Hill Health Professions Division, 1994, ed 2, pp 1384–1396.
 
2. Murray JA. The widening spectrum of celiac disease. Am J Clin Nutr 1999; 69: 354–365.
 
3. George JN, Rizvi MA. Thrombocytopenia, in Beutler E, Williams WJ (eds): Williams Hematology. New York, McGraw-Hill, 2001, ed 6, pp 1495–1527.
 
4. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000; 119: 234–242.
 
5. Jandl JH. Disorders of platelets, in Jandl JH (ed): Blood: Textbook of Hematology. Boston, Little, Brown, 1996, ed 2, pp 1301–1344.
 
6. Eliakim R, Heyman S, Kornberg A. Celiac disease and keratoconjunctivitis: Occurrence with thrombocytopenic purpura. Arch Intern Med 1982; 142: 1037.
 
7. Mulder CJ, Pena AS, Jansen J, Oosterhuis JA. Celiac disease and geographic (serpiginous) choroidopathy with occurrence of thrombocytopenic purpura. Arch Intern Med 1983; 143: 842(letter).
 
8. Mulder CJ, Gratama JW, Trimbos-Kemper GC, Willemze R, Pena AS. Thrombocytopenic purpura, coeliac disease and IgA deficiency. Neth J Med 1986; 29: 165–166.
 
9. Stene-Larsen G, Mosvold J, Ly B. Selective vitamin B12 malabsorption in adult coeliac disease: Report on three cases with associated autoimmune diseases. Scand J Gastroenterol 1988; 23: 1105–1108.
 
10. Sheehan NJ, Stanton-King K. Polyautoimmunity in a young woman. Br J Rheumatol 1993; 32: 254–256.
 
11. Kahn O, Fiel MI, Janowitz HD. Celiac sprue, idiopathic thrombocytopenic purpura, and hepatic granulomatous disease: An autoimmune linkage? J Clin Gastroenterol 1996; 23: 214–216.
 
12. Riggs JE, Schochet SS Jr, Gutmann L, McComas CF, Rogers JS II. Inclusion body myositis and chronic immune thrombocytopenia. Arch Neurol 1984; 41: 93–95.
 
13. Gause A, Inderrieden DC, Laas R, Arlt AC, Gross WL. Common variable immunodeficiency (CVID) and inclusion body myositis (IBM). Immunobiology 2000; 202: 199–203.
 
14. Hadjivassiliou M, Chattopadhyay AK, Davies-Jones GA, Gibson A, Grunewald RA, Lobo AJ. Neuromuscular disorder as a presenting feature of coeliac disease. J Neurol Neurosurg Psychiatry 1997; 63: 770–775.
 
15. Dalakas MC. Polymyositis, dermatomyositis and inclusion-body myositis. N Engl J Med 1991; 325: 1487–1498.