Case Report

Membranoproliferative Glomerulonephritis in Patients with Cystic Fibrosis: Coincidence or Comorbidity? A Case Series

Authors: Edwin Soriano, MD, Daniel Fischman, MD, Pramil Cheriyath, MD

Abstract

The pathogenesis of Brunner gland hamartoma of the duodenum is unknown. This case report describes the chronology of the development of Brunner gland hamartoma from Brunner gland hyperplasia over a 12-year interval. The study subject, a 64-year-old man with chronic iron deficiency anemia, underwent serial upper endoscopies during this period. Repeated endoscopies demonstrated the evolution of Brunner gland hyperplasia, as manifest endoscopically by a submucosal mass, to a pedunculated polyp with histologic features of Brunner gland hamartoma. The duodenal polypoid mass was removed by snare polypectomy. The patient also had a chronic Helicobacter pylori infection of the stomach. This report details the time-dependent evolution of Brunner gland hyperplasia to hamartoma in association with chronic gastric H. pylori infection.


Key Points


* The evolution of Brunner gland hyperplasia to hamartoma is time-dependent.


* Chronic Helicobacter pylori infection is associated with the development of Brunner gland hamartoma.

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